Alpha-melanocyte stimulating hormone plays an important role in the regulation of food intake by the central melanocortin system in chicks
Alpha-melanocyte stimulating hormone plays an important role in the regulation of food intake by the central melanocortin system in chicks
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DOI：
10.1016/j.peptides.2011.03.006
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发表时间：
2011-05-01
期刊：
影响因子：
3
通讯作者：
Hasegawa, Shin
中科院分区：
文献类型：
--
作者：
Saneyasu, Takaoki;Honda, Kazuhisa;Hasegawa, Shin
哺乳动物下丘脑的原黑素皮质素（POMC）神经元在食物摄入的中枢调节中起重要作用。有证据表明，人类黑素皮质素肽α -、β -和γ - 2-黑色素细胞刺激激素（α -、β -和γ - 2-MSH）显著减少了鸡的食物摄入量。然而，鸡的β -和γ - msh的氨基酸序列与人类不同，而α - msh的氨基酸序列在这些物种之间是保守的。在本研究中，我们研究了α -、鸡β -和鸡γ - 2-MSH的中央管理对雏鸡食物摄入量的影响。中央给药α - msh显著抑制雏鸡的食物摄入量。相比之下，β -和γ - 2-MSH对雏鸡的食物摄入量没有影响。HS014（一种黑素皮质素4受体拮抗剂）的集中管理显著逆转了α - msh的厌食作用，这表明这种作用是由雏鸡和哺乳动物的黑素皮质素4受体介导的。这些结果表明，α - msh可能在雏鸡中央黑素皮质素系统对食物摄取量的调节中发挥重要作用。(C) 2011爱思唯尔公司版权所有。
Proopiomelanocortin (POMC, a precursor of melanocortin peptides) neurons in the hypothalamus play an important role in the central regulation of food intake in mammals. There is evidence that human melanocortin peptides alpha-, beta- and gamma2-melanocyte-stimulating hormone (alpha-, beta- and gamma 2-MSH) significantly decreased food intake in chickens. However, the amino acid sequences of beta- and gamma 2-MSH of chickens are different from those of humans whereas the amino acid sequence of alpha-MSH is conserved between these species. In the present study, we examined the effects of the central administration of alpha-, chicken beta-, and chicken gamma 2-MSH on food intake in chicks. Central administration of alpha-MSH significantly suppressed food intake in chicks. In contrast, beta- and gamma 2-MSH did not influence food intake in chicks. Central administration of HS014, a melanocortin 4 receptor antagonist, significantly reversed the anorexigenic action of alpha-MSH, suggesting that this action is mediated by the melanocortin 4 receptor in chicks as well as in mammals. These results suggest that alpha-MSH may play an important role in the regulation of food intake by the central melanocortin system in chicks. (C) 2011 Elsevier Inc. All rights reserved.