Efficacy of Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Refractory Obsessive-Compulsive Disorder: A Clinical Cohort of 70 Patients
Efficacy of Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Refractory Obsessive-Compulsive Disorder: A Clinical Cohort of 70 Patients
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DOI：
10.1176/appi.ajp.2019.19060656
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发表时间：
2020-03-01
影响因子：
17.7
通讯作者：
Schuurman, Rick
中科院分区：
文献类型：
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作者：
Denys, Damiaan;Graat, Ilse;Schuurman, Rick
目的：深部脑刺激（DBS）是难治性强迫症（OCD）患者的有效治疗选择。然而，DBS 治疗强迫症的临床经验仍然有限。作者在一项针对难治性强迫症患者的开放研究中检验了 DBS 的耐受性和有效性。方法：2005 年 4 月至 2017 年 10 月期间，连续 70 名患者（包括先前试验中的 16 名患者）接受了内囊腹前肢 (vALIC) 双侧 DBS 治疗，并随访了 12 个月。主要有效性通过耶鲁-布朗强迫量表 (Y-BOCS) 评分从基线到 12 个月随访的变化进行评估。缓解定义为 Y-BOCS 评分下降 >= 35%，部分缓解定义为下降 25%-34%，无缓解定义为 Y-BOCS 评分下降 35%。
Objective: Deep brain stimulation (DBS) is an effective treatment option for patients with refractory obsessive-compulsive disorder (OCD). However, clinical experience with DBS for OCD remains limited. The authors examined the tolerability and effectiveness of DBS in an open study of patients with refractory OCD.Methods: Seventy consecutive patients, including 16 patients from a previous trial, received bilateral DBS of the ventral anterior limb of the internal capsule (vALIC) between April 2005 and October 2017 and were followed for 12 months. Primary effectiveness was assessed by the change in scores on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) from baseline until the 12-month follow-up. Response was defined by a >= 35% decrease in Y-BOCS score, partial response was defined by a 25%-34% decrease, and nonresponse was defined by a