SuFEx Activation with Ca(NTf2)2 : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides
SuFEx Activation with Ca(NTf2)2 : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides
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DOI：
10.1021/acs.orglett.0c01397
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发表时间：
2020-06-05
期刊：
影响因子：
5.2
通讯作者：
Ball, Nicholas D.
中科院分区：
文献类型：
--
作者：
Mahapatra, Subham;Woroch, Cristian P.;Ball, Nicholas D.
描述了用三氟甲酰亚胺钙和 DABCO 与胺活化氨磺酰氟、氟硫酸盐和磺酰氟的方法，以生成 SuFEx。该反应在室温和温和条件下应用于多种磺酰胺、氨基磺酸盐和磺酰胺。此外，我们强调这种向平行药物化学的转变，以产生广泛的氮基 S(VI) 化合物。
A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.