Left superior parietal cortex involvement in writing: integrating fMRI with lesion evidence
Left superior parietal cortex involvement in writing: integrating fMRI with lesion evidence
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DOI：
10.1016/s0926-6410(01)00063-5
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发表时间：
2001-10-01
期刊：
影响因子：
--
通讯作者：
Desmond, JE
中科院分区：
文献类型：
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作者：
Menon, V;Desmond, JE
写作是一项独特的人类技能，我们几乎每天都在使用。对格斯特曼综合征患者的损伤研究表明，顶叶皮层对书写至关重要。然而，关于正常健康个体负责书写的大脑区域的精确解剖位置的信息很少。在这项研究中，我们使用功能性磁共振成像（fMRI）来研究书写到听写过程中的顶叶功能。左侧上顶叶有明显的激活簇。前额叶（SPL）和与SPL相邻的下顶叶皮层（IPC）的背侧。在左侧运动前皮质、感觉运动皮质和辅助运动区也观察到局部的激活簇。在右半球未观察到激活簇。这些结果清楚地表明，书写似乎主要是在语言主导半球组织的。进一步的分析显示，在顶叶皮层内，左侧SPL的激活明显大于左侧IPC。结合病变研究，本研究的结果进一步证明了左SPL在书写中的重要作用。在本研究中发现的左半球顶叶皮层区域的缺陷可能是格斯特曼综合征和实用性失写症中观察到的书写障碍的具体基础。(C) 2001 Elsevier Science版权所有
Writing is a uniquely human skill that we utilize nearly everyday. Lesion studies in patients with Gerstmann's syndrome have pointed to the parietal cortex as being critical for writing. Very little information is, however, available about the precise anatomical location of brain regions subserving writing in normal healthy individuals. In this study, we used functional magnetic resonance imaging (fMRI) to investigate parietal lobe function during writing to dictation. Significant clusters of activation were observed in left superior parietal. lobe (SPL) and the dorsal aspects of the inferior parietal cortex (IPC) bordering the SPL. Localized clusters of activation were also observed in the left premotor cortex, sensorimotor cortex and supplementary motor area. No activation cluster was observed in the right hemisphere. These results clearly indicate that writing appears to be primarily organized in the language-dominant hemisphere. Further analysis revealed that within the parietal cortex, activation was significantly greater in the left SPL, compared to left IPC. Together with lesion studies, findings from the present study provide further evidence for the essential role of the left SPL in writing. Deficits to the precise left hemisphere parietal cortex regions identified in the present study may specifically underlie disorders of writing observed in Gerstmann's syndrome and apractic agraphia. (C) 2001 Elsevier Science BY All rights reserved.