World Health Organization Ranking of Antimicrobials According to Their Importance in Human Medicine: A Critical Step for Developing Risk Management Strategies to Control Antimicrobial Resistance From Food Animal Production
World Health Organization Ranking of Antimicrobials According to Their Importance in Human Medicine: A Critical Step for Developing Risk Management Strategies to Control Antimicrobial Resistance From Food Animal Production
复制标题
DOI：
10.1093/cid/ciw475
复制
发表时间：
2016-10-15
影响因子：
11.8
通讯作者：
Aidara-Kane, Awa
中科院分区：
文献类型：
--
作者：
Collignon, Peter C.;Conly, John M.;Aidara-Kane, Awa
在食用动物中使用抗菌素是因为细菌具有抗菌素耐药性，这种耐药性可以传播给人类。减少在食品生产动物中使用抗菌素，特别是那些被认为对人类医学至关重要的抗菌素，仍然是保持这些抗菌素对人类益处的重要一步。世界卫生组织根据其在人类医学中的相对重要性对抗菌素的排名最近进行了更新。在至关重要的抗菌素中，被认为最优先的抗菌素是喹诺酮类、第三代和第四代头孢菌素、大环内酯类和酮内酯类以及糖肽类。更新后的排名使农业部门和监管机构的利益相关者能够将风险管理工作重点放在对人类医学最重要的食用动物中使用的药物上。特别是，目前氟喹诺酮类药物、大环内酯类药物和第三代头孢菌素的大规模使用以及糖肽和碳青霉烯类药物的任何潜在使用都需要紧急解决。
Antimicrobial use in food animals selects for antimicrobial resistance in bacteria, which can spread to people. Reducing use of antimicrobials-particularly those deemed to be critically important for human medicine-in food production animals continues to be an important step for preserving the benefits of these antimicrobials for people. The World Health Organization ranking of antimicrobials according to their relative importance in human medicine was recently updated. Antimicrobials considered the highest priority among the critically important antimicrobials were quinolones, third-and fourth-generation cephalosporins, macrolides and ketolides, and glycopeptides. The updated ranking allows stakeholders in the agriculture sector and regulatory agencies to focus risk management efforts on drugs used in food animals that are the most important to human medicine. In particular, the current large-scale use of fluoroquinolones, macrolides, and third-generation cephalosporins and any potential use of glycopeptides and carbapenems need to be addressed urgently.