Phosphine-catalyzed (3 2)/(2 3) sequential annulation involving a triple nucleophilic addition reaction of γ-vinyl allenoates
Phosphine-catalyzed (3 2)/(2 3) sequential annulation involving a triple nucleophilic addition reaction of γ-vinyl allenoates
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膦催化的 (3 2)/(2 3) 顺序环化涉及 γ-乙烯基联烯酸酯的三重亲核加成反应
DOI：
10.1039/c9cc07346a
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Huang You
中科院分区：
文献类型：
--
作者：
Feng Jiaxu;Huang You
研究了膦催化的γ-烯基-联烯酸酯（γ-vinyl allenoates）的（3+2）/（2+3）顺序成环反应。该反应在温和的反应条件下以良好至优异的产率提供了有效且更实用的官能化的吡咯并咪唑酮的途径。值得注意的是，γ-乙烯基丙二烯酸酯在该方案中充当三重亲电子中间体。
A phosphine-catalyzed (3+2)/(2+3) sequential annulation involving a triple nucleophilic addition reaction of γ-vinyl allenoates was successfully developed. The reaction provided efficient and more practical access to functionalized hydropyrroloimidazolones with good to excellent yields under mild reaction conditions. Notably, γ-vinyl allenoate served as a triple-electrophilic intermediate in this protocol.