[Studies on the phenolic acid constituents from Chinese medicine "sheng-ma", rhizome of Cimicifuga foetida L].
[Studies on the phenolic acid constituents from Chinese medicine "sheng-ma", rhizome of Cimicifuga foetida L].
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发表时间：
2002-07
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通讯作者：
Xiao-hong Zhao;Di-hua Chen;J. Si;R. Pan;Lian-gang Shen
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作者：
Xiao-hong Zhao;Di-hua Chen;J. Si;R. Pan;Lian-gang Shen
目的从中药升麻的根茎中寻找新的活性成分。方法采用硅胶柱色谱和SephadexLH-20柱色谱进行分离纯化。通过光谱分析和化学反应确定了它们的结构。结果分离得到8个化合物，分别鉴定为升麻酸（1）、七叶壳（2）、咖啡酸甲酯（3）、4-O-乙酰基咖啡酸（4）、芥子酸（5）、咖啡酸（6）、阿魏酸（7）、异阿魏酸（8）。结论化合物1为新化合物，化合物2-7为首次从该植物中分离得到。
AIM To look for new active constituents from Chinese medicine "Sheng-ma", rhizome of Cimicifuga foetida L. METHODS The compounds were separated and purified by chromatography on silica gel and Sephadex LH-20. Their structures were determined by spectral analysis and chemical reaction. RESULTS Eight compounds were obtained and identified as cimicifugic acid (1), esculetin (2), caffeic acid methyl ester (3), 4-O-acetyl-caffeic acid (4), sinapic acid (5), caffeic acid (6), ferulic acid (7), isoferulic acid (8). CONCLUSION Compound 1 is a new compound, and compounds 2-7 were isolated from this plant for the first time.