Association of polychlorinated biphenyls with hypertension in the 1999-2002 National Health and Nutrition Examination Survey
Association of polychlorinated biphenyls with hypertension in the 1999-2002 National Health and Nutrition Examination Survey
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DOI：
10.1016/j.envres.2008.05.006
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发表时间：
2008-09-01
影响因子：
8.3
通讯作者：
Matheson, Eric M.
中科院分区：
文献类型：
--
作者：
Everett, Charles J.;Mainous, Arch G., III;Matheson, Eric M.
1999-2002 年国家健康和营养调查 (NHANES) 对 11 种多氯联苯 (PCB) 与高血压的关联进行了调查。根据所分析的化学物质，接受高血压评估的未加权参与者人数从 2074 人到 2556 人不等。在未经调整的逻辑回归中，所有 11 种 PCB 均与高血压相关。在调整年龄、性别、种族、吸烟状况、体重指数、运动、总胆固醇和冠心病家族史后，11种PCB中的7种（PCB 126、74、118、99、138/158、170和187）与高血压显着相关。调整后的二恶英样 PCB 126 和 118 与高血压的相关性最强。 PCB 126 > 59.1 pg/g 脂质调整后的优势比为 2.45 (95% CI 1.48-4.04) PCB 126 27.5 ng/g 脂质调整后的优势比为 2.30 (95% CI 1.29-4.08)至 PCB 118 = 20 岁的美国非收容人口。我们假设七种 PCB 与高血压相关，表明 PCB 升高是高血压的危险因素。鉴于这项研究的结果，临床医生能做的事情是有限的，除非可以更广泛地使用适当的实验室方法来检测患者。 (C) 2008 Elsevier Inc. 保留所有权利。
The association of 11 polychlorinated biphenyls (PCBs) with hypertension was investigated using the National Health and Nutrition Examination Survey (NHANES), 1999-2002. The unweighted number of participants assessed for hypertension ranged from 2074 to 2556 depending on the chemical(s) being analyzed. In unadjusted logistic regressions all 11 PCBs were associated with hypertension. After adjustment for age, gender, race, smoking status, body mass index, exercise, total cholesterol, and family history of coronary heart disease, seven of the 11 PCBs (PCBs 126, 74, 118, 99, 138/158, 170, and 187) were significantly associated with hypertension. The strongest adjusted associations with hypertension were found for dioxin-like PCBs 126 and 118. PCB 126 > 59.1 pg/g lipid adjusted had an odds ratio of 2.45 (95% CI 1.48-4.04) compared to PCB 126 27.5 ng/g lipid adjusted had an odds ratio of 2.30 (95% CI 1.29-4.08) compared to PCB 118 = 20 years old in the non-institutionalized US population. We hypothesize that association of seven PCBs with hypertension indicates elevated PCBs are a risk factor for hypertension. What clinicians can do, given the results of this study, is limited unless the appropriate laboratory methods can be made more widely available for testing patients. (C) 2008 Elsevier Inc. All rights reserved.