Involvement of CRF2 receptor in the brain regions in restraint-induced anorexia
Involvement of CRF2 receptor in the brain regions in restraint-induced anorexia
复制标题
DOI：
10.1097/wnr.0b013e3283487467
复制
发表时间：
2011-07-13
期刊：
影响因子：
1.7
通讯作者：
Shibasaki, Tamotsu
中科院分区：
文献类型：
--
作者：
Ohata, Hisayuki;Shibasaki, Tamotsu
我们已经报道了促肾上腺皮质激素释放因子（CRF）受体亚型，CRF 1和CRF 2，参与应激诱导的厌食症。为了澄清在哪些脑区的CRF受体参与介导应激诱导的厌食症，我们研究了微量注射CRF 1-选择性或CRF 2-选择性拮抗剂到外侧隔或终纹床核（BNST），这是有牵连的调节应激反应的影响。结果表明，注射antisauvagine-30到外侧隔或BNST显着衰减限制引起的厌食症，而注射antalarmin到这些地区没有影响厌食症。这些结果表明，CRF 2受体在侧隔和BNST参与应激诱导的摄食行为抑制机制。NeuroReport 22：494-498（C）2011年威科健康垂直酒吧Lippincott威廉姆斯&威尔金斯。
We have reported that corticotropin-releasing factor (CRF) receptor subtypes, CRF1 and CRF2, are involved in stress-induced anorexia. To clarify in which brain regions the CRF receptor is involved in mediating stress-induced anorexia, we examined the effect of microinjecting CRF1-selective or CRF2-selective antagonist into the lateral septum or the bed nucleus of the stria terminalis (BNST), which are implicated in regulating stress response. The results demonstrated that injecting antisauvagine-30 into the lateral septum or the BNST significantly attenuated restraint-induced anorexia, whereas injecting antalarmin into these regions did not affect anorexia. These results suggest that the CRF2 receptor in the lateral septum and the BNST is involved in the stress-induced inhibitory mechanism of feeding behavior. NeuroReport 22:494-498 (C)2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.