Differential proteomics identification of HSP90 as potential serum biomarker in hepatocellular carcinoma by two-dimensional electrophoresis and mass spectrometry.
Differential proteomics identification of HSP90 as potential serum biomarker in hepatocellular carcinoma by two-dimensional electrophoresis and mass spectrometry.
复制标题
DOI：
10.3390/ijms11041423
复制
发表时间：
2010-03-31
影响因子：
5.6
通讯作者：
Sun L
中科院分区：
文献类型：
--
作者：
Sun Y;Zang Z;Xu X;Zhang Z;Zhong L;Zan W;Zhao Y;Sun L
The aim of the current study is to identify the potential biomarkers involved in Hepatocellular carcinoma (HCC) carcinogenesis. A comparative proteomics approach was utilized to identify the differentially expressed proteins in the serum of 10 HCC patients and 10 controls. A total of 12 significantly altered proteins were identified by mass spectrometry. Of the 12 proteins identified, HSP90 was one of the most significantly altered proteins and its over-expression in the serum of 20 HCC patients was confirmed using ELISA analysis. The observations suggest that HSP90 might be a potential biomarker for early diagnosis, prognosis, and monitoring in the therapy of HCC. This work demonstrates that a comprehensive strategy of proteomic identification combined with further validation should be adopted in the field of cancer biomarker discovery.
登录
查看更多内容
影响因子：
11.2
作者：
Chau, B. Nelson;Diaz, Robert L.;Cleary, Michele A.
通讯作者：
Cleary, Michele A.
影响因子：
50.3
作者：
Isaacs, JS;Xu, WP;Neckers, L
通讯作者：
Neckers, L
影响因子：
3.5
作者：
Fujiyama, S;Tanaka, M;Tomita, K
通讯作者：
Tomita, K
影响因子：
2.9
作者：
Hongsachart, Piyorot;Huang-Liu, Rosa;Chen, Shui-Tein
通讯作者：
Chen, Shui-Tein
影响因子：
4.4
作者：
Corzett, Todd H.;Fodor, Imola K.;McCutchen-Maloney, Sandra L.
通讯作者：
McCutchen-Maloney, Sandra L.