Mechanical preprocessing of amplitude-modulated sounds in the apex of the cochlea
Mechanical preprocessing of amplitude-modulated sounds in the apex of the cochlea
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DOI：
10.1159/000095281
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发表时间：
2006-01-01
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影响因子：
--
通讯作者：
Cooper, Nigel P.
中科院分区：
文献类型：
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作者：
Cooper, Nigel P.
用位移敏感的激光干涉仪记录了豚鼠耳蜗顶回中单个Hensen细胞的声诱发振动。研究了对调幅（AM）音调的机械响应，结果表明其在生理上是脆弱的。在健康的耳蜗中，AM响应在中等和高声压水平下都被强烈解调。在不太健康和死后的耳蜗中，AM解调较弱，仅在高刺激水平下可见。解调的生理上脆弱的组成部分被认为是一个模拟的基线位置的变化，可以看到在顶端耳蜗的纯音刺激的反应，并可能起源于耳蜗的外毛细胞的细胞运动。版权所有（c）2006 S. Karger AG，巴塞尔。
Sound-evoked vibrations of individual Hensen's cells in the apical turn of a living guinea pig cochlea were recorded using a displacement-sensitive laser interferometer. The mechanical responses to amplitude-modulated (AM) tones were investigated, and are shown to be physiologically vulnerable. In the healthy cochlea, the AM responses are demodulated strongly at both moderate and high sound pressure levels. In the less healthy and postmortem cochlea, AM demodulation is weaker and is only seen at high stimulus levels. The physiologically vulnerable component of the demodulation is considered to be an analogue of the baseline position shifts that can be seen in the apical cochlea's responses to pure-tone stimuli, and is likely to originate in the cellular motility of the cochlea's outer hair cells. Copyright (c) 2006 S. Karger AG, Basel.