SUMO-mediated regulation of DNA damage repair and responses.
SUMO-mediated regulation of DNA damage repair and responses.
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DOI：
10.1016/j.tibs.2015.02.006
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发表时间：
2015-04
影响因子：
13.8
通讯作者：
Zhao, Xiaolan
中科院分区：
文献类型：
--
作者：
Sarangi, Prabha;Zhao, Xiaolan
类小泛素化在DNA损伤修复和应答过程中起着重要作用。最近的大范围和基于底物的研究揭示了在这些过程中的sumoylation的调节和意义。一个新兴的范例是，许多DNA代谢蛋白的类小泛素化是由DNA接合控制的。这种“原位修饰”可以解释低底物修饰水平，并在类小泛素化机制和效应中具有重要意义。新的研究还表明，类小泛素化可以通过整体效应或通过主要底物调节一个过程。此外，我们描述了sumo化的功能效应的新趋势，如生物分子结合的双向变化和与其他修饰的多级协调。这些新出现的主题和模型将激发我们对类泛素化和基因组维护的思考和研究。
Sumoylation plays important roles during DNA damage repair and responses. Recent broad-scope and substrate-based studies have shed light on the regulation and significance of sumoylation during these processes. An emerging paradigm is that sumoylation of many DNA metabolism proteins is controlled by DNA engagement. Such “on-site modification” can explain low substrate modification levels and has important implications in sumoylation mechanisms and effects. New studies also suggest that sumoylation can regulate a process through an ensemble effect or via major substrates. Additionally, we describe new trends in the functional effects of sumoylation, such as bi-directional changes in biomolecule binding and multi-level coordination with other modifications. These emerging themes and models will stimulate our thinking and research in sumoylation and genome maintenance.
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