Cognitive set shifting deficits and their relationship to repetitive behaviors in autism spectrum disorder.
Cognitive set shifting deficits and their relationship to repetitive behaviors in autism spectrum disorder.
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DOI：
10.1007/s10803-014-2244-1
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发表时间：
2015-03
影响因子：
3.9
通讯作者：
Mosconi MW
中科院分区：
文献类型：
--
作者：
Miller HL;Ragozzino ME;Cook EH;Sweeney JA;Mosconi MW
自闭症谱系障碍（ASD）中与受限和重复行为（RRB）相关的神经认知损伤尚不明确。先前的研究表明，自闭症患者表现出认知灵活性降低，这可能反映出从先前习得的反应模式转变困难，或者无法维持新的反应模式。我们对60名自闭症患者和55名年龄及非言语智商匹配的对照组进行了一项集合转换测试，并检查了不同的错误类型。自闭症患者最初能够进行集合转换，但他们在维持新的反应集合方面存在困难。集合维持困难与RRB的严重程度增加有关。普遍难以维持新的反应集合以及更倾向于恢复旧的偏好可能导致RRB。
The neurocognitive impairments associated with restricted and repetitive behaviors (RRBs) in autism spectrum disorder (ASD) are not yet clear. Prior studies indicate that individuals with ASD show reduced cognitive flexibility, which could reflect difficulty shifting from a previously learned response pattern or a failure to maintain a new response set. We examined different error types on a test of set-shifting completed by 60 individuals with ASD and 55 age- and nonverbal IQ-matched controls. Individuals with ASD were able to initially shift sets, but they exhibited difficulty maintaining new response sets. Difficulty with set maintenance was related to increased severity of RRBs. General difficulty maintaining new response sets and a heightened tendency to revert to old preferences may contribute to RRBs.