Cardiac and respiratory activity in panic disorder: effects of sleep and sleep lactate infusions.
Cardiac and respiratory activity in panic disorder: effects of sleep and sleep lactate infusions.
复制标题
惊恐障碍中的心脏和呼吸活动：睡眠和睡眠乳酸输注的影响。
DOI：
10.1176/ajp.151.8.1148
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Kakuma,T
中科院分区：
文献类型：
--
作者：
Koenigsberg,HW;Pollak,CP;Fine,J;Kakuma,T
本研究检查了惊恐障碍患者和健康对照受试者在睡眠期间的心脏和呼吸活动，当焦虑认知和期望集的影响最小化时。记录11名惊恐障碍患者和12名对照受试者在睡眠前和睡眠中以及输注乳酸钠和生理盐水前后的血氧饱和度结果惊恐障碍患者在睡眠开始前和在任何输液前的睡眠阶段0和2期间的氧饱和度高于对照组。两组在其他呼吸变量和心率方面没有差异。与对照组相比，惊恐障碍患者在3-4期睡眠期间对乳酸盐输注有反应，心率和氧饱和度增加更大，呼吸频率和潮气末PCO 2也可能增加。盐水控制输液有很小的影响。ConclusionsThese研究结果表明，恐慌症患者有更大的心脏和呼吸反应比健康的比较对象在睡眠中，当认知因素的影响是最小的或不存在的。
ObjectiveThis study examined cardiac and respiratory activity in panic disorder patients and healthy comparison subjects during sleep, when the effects of anxious cognition and expectancy set are minimized.MethodHeart rate, respiratory rate, end-tidal PCO2, and oxygen saturation were recorded for 11 panic disorder patients and 12 comparison subjects before and during sleep and before and after infusions of sodium lactate and a saline control.ResultsPanic disorder patients had higher oxygen saturations than comparison subjects before sleep onset and during sleep stages 0 and 2 before any infusions. The two groups did not differ on other respiratory variables and heart rate. Panic disorder patients responded to lactate infusions during stage 3-4 sleep with greater increases in heart rate and oxygen saturation, and possibly in respiratory rate and end-tidal PCO2, than comparison subjects. The saline control infusion had little effect.ConclusionsThese findings suggest that panic disorder patients have greater cardiac and respiratory reactivity than healthy comparison subjects during sleep, when the influence of cognitive factors is minimal or absent.