The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases.
The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases.
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DOI：
10.2174/187152109787846060
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发表时间：
2009-04-01
期刊：
影响因子：
--
通讯作者：
Badley AD
中科院分区：
文献类型：
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作者：
Shepard BD;Badley AD
肿瘤坏死因子相关凋亡诱导配体（TNF-related apoptosis inducing ligand，TRAIL）是机体对感染的天然免疫应答的关键介质。虽然TRAIL介导的细胞凋亡在清除病毒感染的细胞中起着重要作用，但其生理作用还包括对癌细胞的免疫监视。在癌细胞中诱导TRAIL介导的细胞凋亡的治疗剂仍然是临床试验中正在进行的研究的焦点，并且已经从这些研究中了解到关于这些干预的功效和毒性的许多内容。这些数据，结合来自许多临床前研究的数据，这些研究详细说明了TRAIL在人类免疫缺陷病毒和其他病毒感染期间的重要和多方面的作用，表明TRAIL信号传导的治疗利用为感染性疾病的管理提供了一种新的有效策略。
TNF-related apoptosis inducing ligand (TRAIL) is a key mediator of the innate immune response to infection. While TRAIL-mediated apoptosis plays an essential role in the clearance of virus-infected cells, its physiologic role also includes immunosurveilance for cancer cells. Therapeutics that induce TRAIL-mediated apoptosis in cancer cells remain a focus of ongoing investigation in clinical trials, and much has been learned from these studies regarding the efficacy and toxicity of these interventions. These data, combined with data from numerous preclinical studies that detail the important and multifaceted role of TRAIL during infection with human immunodeficiency virus and other viruses, suggest that therapeutic exploitation of TRAIL signaling offers a novel and efficacious strategy for the management of infectious diseases.