ALTERATION OF ISLET CELL-POPULATIONS IN SPONTANEOUSLY DIABETIC MICE
ALTERATION OF ISLET CELL-POPULATIONS IN SPONTANEOUSLY DIABETIC MICE
复制标题
DOI：
10.2337/diabetes.27.1.1
复制
发表时间：
1978-01-01
期刊：
影响因子：
7.7
通讯作者：
ORCI, L
中科院分区：
文献类型：
--
作者：
BAETENS, D;STEFAN, Y;ORCI, L
用免疫荧光和形态计量学方法对重度低胰岛素血症突变小鼠(C57BL/KSJ背景为ob/ob或db/db)和轻度高胰岛素血症小鼠(C57BL/6J背景为ob/ob或db/db)的胰岛内分泌细胞数量进行了定量研究。在严重糖尿病小鼠中，与对照组(+/+)小鼠相比，胰岛中含有胰岛素的细胞比例减少，但含有胰升糖素、生长抑素和胰多肽(PP)的细胞增加。在轻度糖尿病小鼠的胰岛中观察到了相反的变化：胰岛肥大，主要由含有胰岛素的细胞组成，含有胰高血糖素、生长抑素和PP的细胞比例降低。在这两种类型的糖尿病综合征中，细胞群的变化导致了受影响胰岛细胞相互关系的质的改变。
Endocrine-cell populations in the islets of Langerhans of mutant mice with a severe hypoinsulinemic diabetes (ob/ob or db/db on the C57BL/KsJ background) or with a mild hyperinsulinemic diabetes (ob/ob or db/db on the C57BL/6J background) were studied quantitatively by immunofluorescence and morphometry. In severely diabetic mice, islets presented a reduced proportion of insulin-containing cells but increased glucagon-, somatostatin- and pancreatic polypeptide (PP)-containing cells, as compared with islets of control (+/+) mice. An inverse change was observed in islets of mildly diabetic mice: islets were hypertrophic and composed mostly of insulin-containing cells, with decreased proportions of glucagon-, somatostatin- and PP-containing cells. In both types of diabetic syndromes, the changes in cell populations induced a qualitative alteration of cellular interrelationships in the affected islets.