Stokes trap for multiplexed particle manipulation and assembly using fluidics
Stokes trap for multiplexed particle manipulation and assembly using fluidics
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DOI：
10.1073/pnas.1525162113
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发表时间：
2016-04-12
影响因子：
11.1
通讯作者：
Schroeder, Charles M.
中科院分区：
文献类型：
--
作者：
Shenoy, Anish;Rao, Christopher V.;Schroeder, Charles M.
限制和操纵单个粒子和分子的能力使几个科学领域发生了革命性的变化。流体动力学捕获为在自由溶液中操纵粒子提供了一种很有吸引力的方法，而不需要光、电、声或磁场。在这里，我们开发和演示了斯托克斯陷阱，这是一种仅使用流体流动来捕获多个粒子的新方法。我们演示了使用模型预测控制在一个简单的微流控装置中同时操纵两个颗粒。我们进一步证明，这种方法可以用于溶液中多个粒子的流体定向组装。总之，这项技术为粒子-粒子相互作用的基础研究开辟了新的前景，并为胶体粒子的定向组装提供了一种新的方法。
The ability to confine and manipulate single particles and molecules has revolutionized several fields of science. Hydrodynamic trapping offers an attractive method for particle manipulation in free solution without the need for optical, electric, acoustic, or magnetic fields. Here, we develop and demonstrate the Stokes trap, which is a new method for trapping multiple particles using only fluid flow. We demonstrate simultaneous manipulation of two particles in a simple microfluidic device using model predictive control. We further show that this approach can be used for fluidic-directed assembly of multiple particles in solution. Overall, this technique opens new vistas for fundamental studies of particle-particle interactions and provides a new method for the directed assembly of colloidal particles.