The long-lasting effects of cross-fostering on the emotional behavior in ICR mice
The long-lasting effects of cross-fostering on the emotional behavior in ICR mice
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DOI：
10.1016/j.bbr.2008.10.031
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发表时间：
2009-03-02
影响因子：
2.7
通讯作者：
Nabeshima, Toshitaka
中科院分区：
文献类型：
--
作者：
Lu, Lingling;Mamiya, Takayoshi;Nabeshima, Toshitaka
出生后的早期生活压力可能会导致人类情感表达的功能特性发生长期变化，但交叉寄养的心理压力如何影响小鼠成年期的情感行为仍然是未知的。本研究旨在探讨交叉寄养对ICR子代成年期情绪行为和认知功能的长期影响。从出生后第7天开始进行交叉寄养，共3周。将小鼠分为三组：（1）生物组：由其原始母亲抚养的ICR母鼠所生的幼仔;（2）寄养组：由ICR母鼠所生但被其他ICR母鼠收养的幼仔;（3）交叉寄养组：由C57母鼠收养的ICR幼仔。ICR小鼠在8周龄时进行行为实验。在旷场、高架十字迷宫和强迫游泳测试以及社会互动测试中，交叉培养小鼠的情绪行为发生了显著改变。然而，交叉培养的小鼠在Y-迷宫和新物体识别测试中表现出正常的记忆功能。结果表明，交叉寄养可使大鼠前额叶皮层和海马5-羟色胺代谢产物含量降低，提示交叉寄养可使大鼠大脑皮质5-羟色胺能神经元功能受损。这些结果表明，早期生活的压力，交叉寄养引起长期的情绪异常，这可能是与5-羟色胺代谢的改变。(C)2008 Elsevier B. V.保留所有权利。
Early-life stress during the postnatal period could precipitate long-lasting alterations in the functional properties underlying emotional expression in humans,but how the psychological stress of cross-fostering affects emotional behavior during adulthood in mice remains primarily unknown. The purpose of the present study was to examine the long-term effects of cross-fostering on the emotional behavior and cognitive functions of ICR offspring in adulthood. Cross-fostering was performed from postnatal day 7 for 3 weeks. Mice were divided into three groups: (1) biological group: pups born from ICR dams fostered by their original mothers; (2) in-foster group: pups born from ICR dams but adopted by other ICR dams and (3) cross-foster group: ICR pups adopted by C57 dams. ICR mice were subjected to behavioral experiments at the age of 8 weeks. Emotional behaviors in the cross-fostered mice were significantly altered in the open-field, elevated plus maze and forced swimming tests, as well as social interaction tests. However, the cross-fostered mice showed normal memory function in the Y-maze and novel object recognition tests. The contents of serotonin metabolisms were decreased in the prefrontal cortex and hippocampus indicated the deficit of serotoninergic neuronal function by cross-fostering. These findings suggested that the early-life stress of cross-fostering induced long-lasting emotional abnormalities, which might be possibly related to alterations of serotonin metabolisms. (C) 2008 Elsevier B.V. All rights reserved.