Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system
Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system
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DOI：
10.1039/b403378g
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发表时间：
2004-01-01
期刊：
影响因子：
6.1
通讯作者：
Ismagilov, RF
中科院分区：
文献类型：
--
作者：
Shestopalov, I;Tice, JD;Ismagilov, RF
本文报道了一种基于插件的微流控方法，用于进行毫秒级时间控制的多步化学反应。它建立在先前报道的方法的基础上，其中将水性试剂注入到不混溶流体（碳氟化合物）流中（H. Song等人，Angew.化学国际版，2003，42，768）。水性试剂形成由不混溶流体包围和输送的塞-液滴。蜿蜒的通道将试剂迅速混合成液滴。这篇论文表明，反应的进一步阶段可以通过将额外的试剂流直接流入初始反应混合物的液滴中来启动。表征了水性流与水性液滴合并所需的条件。毛细管数可以用来预测两相流在汇流处的流动行为。通过在液滴中输送固体反应产物，防止产物聚集在微通道的壁上。为了证明这种微流体方法的实用性，它被用来合成胶体CdS和CdS/CdSe核壳纳米粒子。
This paper reports a plug-based, microfluidic method for performing multi-step chemical reactions with millisecond time-control. It builds upon a previously reported method where aqueous reagents were injected into a flow of immiscible fluid (fluorocarbons) (H. Song et al., Angew. Chem. Int. Ed., 2003, 42, 768). The aqueous reagents formed plugs-droplets surrounded and transported by the immiscible fluid. Winding channels rapidly mixed the reagents in droplets. This paper shows that further stages of the reaction could be initiated by flowing additional reagent streams directly into the droplets of initial reaction mixture. The conditions necessary for an aqueous stream to merge with aqueous droplets were characterized. The Capillary number could be used to predict the behavior of the two-phase flow at the merging junction. By transporting solid reaction products in droplets, the products were kept from aggregating on the walls of the microchannels. To demonstrate the utility of this microfluidic method it was used to synthesize colloidal CdS and CdS/CdSe core-shell nanoparticles.