Longitudinal change in components of astigmatism and its association with axial length-corneal radius ratio in Chinese young children: the Nanjing Eye Study
Longitudinal change in components of astigmatism and its association with axial length-corneal radius ratio in Chinese young children: the Nanjing Eye Study
复制标题
中国幼儿散光成分的纵向变化及其与眼轴-角膜半径比的关系：南京眼科研究
DOI：
10.1007/s00417-021-05386-8
复制
发表时间：
2021-08-26
影响因子：
2.7
通讯作者：
Zhu, Hui
中科院分区：
文献类型：
--
作者：
Li, Xiaoxiao;Li, Rui;Zhu, Hui
目的：评估4至7岁儿童散光成分的纵向变化及其与轴长 - 角膜曲率半径比（AL/CR）的关联。方法：2015年起，邀请2011年9月至2012年8月在南京雨花台区出生的儿童参加南京眼研究，每年进行一次全面的眼部检查。本文所呈现的数据来自2016年、2017年和2019年。在每次研究中，测量非睫状肌麻痹自动验光和眼部生物测量参数。以临床标记法（柱镜度数，Cyl）和矢量标记法（J(0)、J(45)）分析总散光（TA）、角膜散光（CA）、角膜前表面散光（ACA）、剩余散光（RA）和眼内散光（IA）的变化。结果：954名儿童（基线年龄均值±标准差：4.63±0.29岁，男孩占53.7%）有完整数据并被纳入本研究。以柱镜度数标记法表示的纵向变化平均斜率，TA、CA和ACA显著为负，而IA为正。J(0)标记法的TA、CA、ACA和RA有向顺规散光（WTR）增加和/或逆规散光（ATR）减少的转变。J(45)标记法的TA显示在135度轴位散光增加和/或在45度轴位散光减少，而J(45)标记法的CA和ACA显示相反变化。ACA和IA的纵向变化在J(0)标记法中呈负相关，但在J(45)标记法中无此相关性。基于补偿因子（CF，定义为IA与ACA的负比值），2016年、2017年和2019年J(0)在不同程度（CF：0.1 - 2）的补偿比例分别为91.3%、93.5%和90.0%，而J(45)分别为74.9%、76.5%和34.6%。较高的AL/CR增长与柱镜度数标记法的CA和ACA减少较少或增加较多相关，且在J(0)标记法中与向顺规散光增加和/或逆规散光减少相关。结论：在中国幼儿中，从4岁到7岁，对于J(0)标记法，IA的补偿作用持续且显著。AL/CR的进展与源于角膜的散光相关。
PurposeTo assess the longitudinal change in components of astigmatism from age 4 to 7 years and its association with axial length-corneal radius ratio (AL/CR).MethodsChildren born between September 2011 and August 2012 in Yuhuatai District of Nanjing were invited to participate in the Nanjing Eye Study for a comprehensive eye examination annually since 2015. The data presented in this paper were obtained in 2016, 2017, and 2019. At each study encounter, noncycloplegic autorefraction and ocular biometric parameters were measured. Changes of total astigmatism (TA), corneal astigmatism (CA), anterior corneal astigmatism (ACA), residual astigmatism (RA), and internal astigmatism (IA) were analyzed in clinical notation (Cyl) and vector notation (J0, J45).ResultsNine hundred fifty-four children (mean ± standard deviation of baseline age: 4.63 ± 0.29 years, 53.7% boys) had complete data and were included in this study. Mean slopes of longitudinal changes in Cyl notation were significantly negative for TA, CA, and ACA, but positive for IA. TA, CA, ACA, and RA of J0notation had a shift toward increasing with-the-rule (WTR) astigmatism and/or decreasing against-the-rule (ATR) astigmatism. TA of J45notation showed an increase in astigmatism at axis 135° and/or a decrease in astigmatism at axis 45°, while CA and ACA of J45notation showed an opposite change. Longitudinal changes in ACA and IA were negatively correlated in J0notation, but not in J45notation. Based on compensation factor (CF, defined as the minus ratio of IA and ACA), the compensation proportions for J0in varying degrees (CF: 0.1–2) in 2016, 2017, and 2019 were 91.3%, 93.5%, and 90.0%, respectively, while these for J45were 74.9%, 76.5%, and 34.6%, respectively. Higher AL/CR increase was associated with less decrease or more increase in CA and ACA of Cyl notation, and a shift toward increasing WTR and/or decreasing ATR in these of J0notation.ConclusionsThe compensatory role of IA was persistent and prominent from 4 to 7 years old for J0notation in Chinese young children. The progression of AL/CR was correlated with astigmatism originated from the cornea.