MECHANISM OF TIMOLOL IN LOWERING INTRA-OCULAR PRESSURE - IN NORMAL EYE
MECHANISM OF TIMOLOL IN LOWERING INTRA-OCULAR PRESSURE - IN NORMAL EYE
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DOI：
10.1001/archopht.1978.03910060433007
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
BRUBAKER, RF
中科院分区：
文献类型：
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作者：
COAKES, RL;BRUBAKER, RF
马来酸噻吗洛尔β-受体拮抗剂的眼压降低特性的机制的单滴、双盲、随机、安慰剂对照研究肾上腺素能受体阻滞剂，在23名正常人进行了荧光光度法。噻吗洛尔抑制所有受试者的房水形成。抑制的范围为13- 48%，平均值为. ±. SD为34%+-。百分之九。该药物对前房容积或内皮细胞对荧光素的通透性没有影响，显然对流出阻力没有影响。对男性和女性的影响以及对浅色和深色虹膜的影响没有差异。
A single-drop, double-masked, randomized, placebo-controlled study of the mechanism of the ocular-pressure lowering property of timolol maleate, a .beta.-adrenergic blocker, was carried out in 23 normal subjects, using fluorophotometry. Timolol suppressed aqueous formation in all subjects. The range of suppression was 13-48%, with a mean .+-. SD of 34% .+-. 9%. The drug had no effect on anterior chamber volume or endothelial permeability to fluorescein and apparently had no effect on outflow resistance. No differences were observed between its effect on men and women or between eyes with light and dark irides.