Subjective Mild Depressive Symptoms are Associated With Abnormal Diurnal Cycle of Salivary Cortisol in Older Adults
Subjective Mild Depressive Symptoms are Associated With Abnormal Diurnal Cycle of Salivary Cortisol in Older Adults
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DOI：
10.1177/0891988710373599
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发表时间：
2011-03-01
影响因子：
2.6
通讯作者：
Bromberg, Elke
中科院分区：
文献类型：
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作者：
Balardin, Joana Bisol;Vedana, Gustavo;Bromberg, Elke
背景：皮质醇分泌模式的改变似乎与衰老、抑郁和认知能力下降有关。目的：本研究的目的主要是评估有主观抑郁症状的老年人的皮质醇昼夜节律。研究方法：分别于上午7点、下午4点和晚上10点采集健康青年人（n = 22）、老年人（n = 22）和在老年抑郁量表中自报抑郁症状的老年人（n = 22）的唾液皮质醇样本，并通过放射免疫法进行分析。结果如下：有抑郁症状的老年人呈现出典型的皮质醇昼夜节律模式，但他们在晚上10点时的皮质醇水平高于健康的年轻人和老年人。结论：我们的数据表明，轻度抑郁症状可能与皮质醇分泌模式有关，以前被描述为预测认知能力下降。
Background: Alterations in cortisol secretion pattern seem to be involved in the associations between aging, depression, and cognitive decline. Objective: The aim of this study was to mainly assess cortisol circadian profile in older adults with subjective depressive symptoms. Methods: Salivary cortisol samples from healthy young (n = 22) and old adults (n = 22), and from older adults who self-reported depressive symptoms in Geriatric Depression Scale (n = 22) were collected at 7 AM, 4 PM, and 10 PM and were analyzed by radioimmunoassay. Results: Older adults with depressive symptoms presented the characteristic cortisol circadian pattern, but they showed higher cortisol levels at 10 PM than healthy young and elderly controls. Conclusions: Our data suggest that mild depressive symptoms could be associated with a cortisol secretion pattern previously described as being predictive of cognitive decline.