Monkeys and Rats Are Not Susceptible to Ferret Hepatitis E Virus Infection
Monkeys and Rats Are Not Susceptible to Ferret Hepatitis E Virus Infection
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DOI：
10.1159/000373891
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发表时间：
2015-04
期刊：
影响因子：
4.6
通讯作者：
Tiancheng Li;Sayaka Yoshizaki;Y. Ami;Y. Suzaki;Tingting Yang;N. Takeda;Wakita Takaji
中科院分区：
文献类型：
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作者：
Tiancheng Li;Sayaka Yoshizaki;Y. Ami;Y. Suzaki;Tingting Yang;N. Takeda;Wakita Takaji
雪貂戊型肝炎病毒（HEV）是一种新型的戊型肝炎样病毒，已在荷兰，日本和美国的雪貂中发现。为了确定雪貂HEV是否传播给其他动物，我们通过静脉注射将雪貂HEV（F4351）接种给实验室大鼠（Wistar）、裸大鼠（Long-Evans-rnu/rnu）和食蟹猴。没有一只动物表现出病毒复制的阳性迹象，表明大鼠和猴子对雪貂HEV不敏感。
Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has been identified in ferrets in the Netherlands, Japan, and the US. To determine whether ferret HEV transmits to other animals, we inoculated laboratory rats (Wistar), nude rats (Long-Evans-rnu/rnu), and cynomolgus monkeys with ferret HEV (F4351) by intravenous injection. None of the animals demonstrated a positive sign for virus replication, indicating that rats and monkeys are not susceptible to ferret HEV.