Dependency of Pial Arterial and Arteriolar Diameter on Perivascular Osmolarity in the Cat: A Microapplication Study
Dependency of Pial Arterial and Arteriolar Diameter on Perivascular Osmolarity in the Cat: A Microapplication Study
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猫的软脑膜动脉和小动脉直径对血管周围渗透压的依赖性：一项微应用研究
DOI：
10.1161/01.res.32.2.162
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发表时间：
1973
影响因子：
20.1
通讯作者：
K. Thurau
中科院分区：
文献类型：
--
作者：
M. Wahl;W. Kuschinsky;O. Bosse;K. Thurau
应用微应用技术研究了猫血管周围渗透压对动脉直径的影响。在251 ~ 360 mosmoles/l范围内，获得了单个容器的浓度-响应曲线。当血管周围渗透压低于317摩摩尔/升时发生收缩，渗透压高于此值时发生扩张。甘露醇和NaCl的加入对渗透压的影响是相同的。在恒定的渗透压下，钠浓度从156 mEq/l降低到133 mEq/l对动脉直径没有影响，但钠浓度的更大降低会引起血管收缩。结果表明，动脉阻力可受局部血管周围渗透压变化的影响。
The effect of perivascular osmolarity on the diameter of pial arteries was studied in cats by the microapplication technique. Between 251 and 360 mosmoles/liter, concentration-response curves were obtained for single vessels. Constriction occurred when perivascular osmolarity was decreased below 317 mosmoles/liter, and dilation occurred at osmolarities above this value. The effect was the same whether the osmolarity was changed by addition of mannitol or NaCl. Reduction of sodium concentration from 156 to 133 mEq/liter at constant osmolarity did not affect arteriolar diameter, but greater reductions in sodium concentration induced vasoconstriction. The results indicate that the resistance of pial arteries can be influenced by local changes in perivascular osmolarity.