HEART-RATE-VARIABILITY IN NORMAL SLEEPING FULL-TERM AND PRETERM NEONATES
HEART-RATE-VARIABILITY IN NORMAL SLEEPING FULL-TERM AND PRETERM NEONATES
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DOI：
10.1016/0378-3782(92)90111-s
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发表时间：
1992-02-01
影响因子：
2.5
通讯作者：
LEFFLER, C
中科院分区：
文献类型：
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作者：
CLAIRAMBAULT, J;CURZIDASCALOVA, L;LEFFLER, C
为评价自主神经系统（ANS）的成熟程度和睡眠状态，对24例孕龄31 ~ 41周的健康睡眠新生儿进行了心率变异性（HRV）研究。通过短时傅立叶变换在三个频带中进行心搏间期（RR）信号的频谱分析：高（HF），纯粹迷走神经起源，中（MF），和低（LF），迷走神经和交感神经，从而允许评估在主动睡眠（AS = REM睡眠）和安静睡眠（QS = nREM睡眠）中观察到的ANS的两个分支。主成分分析，判别分析和假设检验被用来调查光谱变量的演变及其与睡眠状态的关系。HF、MF、LF和平均RR均随年龄增长而增加;从早产儿到足月儿组的差异总体上在AS中比在QS中更显著。HF显示从早产儿（31-36周CA）到中期（37-38）组增加最多，而LF显示从早产儿到中期以及从中期到足月（39-41）组的相同差异。这些结果表明，迷走神经张力在CA 37-38周急剧增加，之后稳定，交感神经张力从CA 31 - 41周更有规律地增加。
To assess maturation of the Autonomic Nervous System (ANS) and sleep states, Heart Rate Variability (HRV) was studied in 24 healthy sleeping newborns, aged from 31 to 41 weeks, conceptional age (CA). Spectral analysis of the interbeat interval (RR) signal, was performed by Short-Time Fourier Transform, in three frequency bands: high (HF), of purely vagal origin, mid (MF), and low (LF), vagal and sympathetic, thus allowing evaluation of both branches of the ANS, observed in Active Sleep (AS = REM Sleep) and in Quiet Sleep (QS = nREM Sleep). Principal Component Analysis, Discriminant Analysis, and hypothesis tests were used to investigate the evolution of spectral variables and their relation with sleep states. HF, MF, LF, and mean RR all increased with age; the differences from the premature to the full-term group, were more marked, as a whole, in AS than in QS. HF showed the highest increase from the premature (31-36 weeks CA) to the intermediate (37-38) group, whereas LF showed equal differences from the premature to the intermediate, and from the intermediate to the full-term (39-41) groups. These results suggest a steep increase in vagal tone at 37-38 weeks CA, with stability afterwards, and a more regular increase in sympathetic tone from 31 to 41 weeks CA.