Risk of epilepsy in type 1 diabetes mellitus: a population-based cohort study
Risk of epilepsy in type 1 diabetes mellitus: a population-based cohort study
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DOI：
10.1007/s00125-016-3929-0
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发表时间：
2016-06-01
期刊：
影响因子：
8.2
通讯作者：
Kao, Chia-Hung
中科院分区：
文献类型：
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作者：
Chou, I-Ching;Wang, Chung-Hsing;Kao, Chia-Hung
目的/假设1型糖尿病是全球日益关注的主要公共卫生问题，具有潜在的神经系统并发症。1型糖尿病与继发性癫痫之间可能存在关联。本研究评估1型糖尿病和癫痫之间的关系在Taiwan.Methods索赔数据从台湾全民健康保险研究数据库进行回顾性队列分析。该研究队列包含2568例1型糖尿病患者，每个人的频率匹配的性别，城市化的居住地区和指数年与10例无1型糖尿病患者。采用考克斯比例风险回归分析方法，估计1型糖尿病对癫痫风险的影响。结果1型糖尿病患者发生癫痫的风险显著高于非1型糖尿病患者（p
Aims/hypothesis Type 1 diabetes mellitus is a major public health problem of increasing global concern, with potential neurological complications. A possible association exists between type 1 diabetes and subsequent epilepsy. This study evaluated the relationship between type 1 diabetes and epilepsy in Taiwan.Methods Claims data from the Taiwan National Health Insurance Research Database were used to conduct retrospective cohort analyses. The study cohort contained 2568 patients with type 1 diabetes, each of whom was frequency-matched by sex, urbanisation of residence area and index year with ten patients without type 1 diabetes. Cox proportional hazard regression analysis was conducted to estimate the effects of type 1 diabetes on epilepsy risk.Results In patients with type 1 diabetes, the risk of developing epilepsy was significantly higher than that in patients without type 1 diabetes (p