POSTURE INFLUENCES MELATONIN CONCENTRATIONS IN PLASMA AND SALIVA IN HUMANS
POSTURE INFLUENCES MELATONIN CONCENTRATIONS IN PLASMA AND SALIVA IN HUMANS
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DOI：
10.1016/0304-3940(94)91059-6
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发表时间：
1994-02-14
影响因子：
2.5
通讯作者：
ARENDT, J
中科院分区：
文献类型：
--
作者：
DEACON, S;ARENDT, J
褪黑素被广泛用作昼夜节律的标志物，因此，除内源性节律性外，任何影响其浓度的因素都必须评估。我们报告了体位对血浆和唾液中褪黑激素浓度的影响。这项研究是在褪黑激素节律上升的21：00至01：30小时之间进行的。从23：00小时起，7名健康受试者保持坐姿至24：00小时，并在暗光(<；10勒克斯)中持续至01：30小时。从24：00小时开始，他们在以下阶段之一呈现不同的姿势：1a阶段：24：00-00：30 h-站立，00：00-01：00 h-仰立，01：00-01：30 h-站立；1b阶段--1a相反；2a阶段：24：00-01：30 h-仰卧；阶段2b：24：00-01：30h--站立。从21：00-24：00每小时采血和唾液标本，24：00-01：30每隔10分钟采一次血和唾液，放射免疫法测定血浆和唾液褪黑素浓度，从仰卧位到立位时升高，反位时下降。与其他血液成分一样，这些变化可以通过重力的影响来解释，重力会导致站立时血浆体积的减少，以及躺下时血浆体积的增加。
Melatonin is extensively used as a circadian marker rhythm and thus any factors influencing its concentrations other than endogenous rhythmicity must be assessed. We report here the effects of posture on melatonin concentrations in plasma and saliva. The study was performed during the rising phase of the melatonin rhythm between 21:00 and 01:30 h. From 23:00 h, 7 healthy subjects remained sitting until 24:00 h and in dim light (< 10 lux) until 01:30 h. From 24:00 h, they assumed a different postural position in one of the following stages: Stage 1a: 24:00-00:30 h - standing, 00:30-01:00 h - supine, 01:00-01:30 h - standing; Stage 1b - reverse of Stage 1a; Stage 2a: 24:00-01:30 h - supine; and Stage 2b: 24:00-01:30 h - standing. Blood and saliva samples were obtained every hour from 21:00-24:00 h and then every 10 min from 24:00-01:30 h. Plasma and salivary melatonin concentrations, measured by radioimmunoassay, increased when moving from a supine to a standing position and decreased when these positions were reversed. These changes, as seen with other blood components, can be explained through the influence of gravity which causes a decrease in plasma volume on standing and an increase in plasma volume on lying down.