Fetal lipoprotein changes in pre-eclampsia
Fetal lipoprotein changes in pre-eclampsia
复制标题
DOI：
10.1080/00016340802085318
复制
发表时间：
2008-01-01
影响因子：
4.3
通讯作者：
Santos-Silva, Alice
中科院分区：
文献类型：
--
作者：
Catarino, Cristina;Rebelo, Irene;Santos-Silva, Alice
Objective.通过同时检测母血和脐带血血脂水平，探讨子痫前期（PE）孕妇血脂变化对胎儿的影响。设计对健康和先兆子痫孕妇及其新生儿进行病例对照研究。设置. S医院妇产科。若昂和药学院，波尔图，葡萄牙。样品42例健康妊娠和46例妊娠合并PE。方法.采用酶法测定总胆固醇（TChol）、HDL-胆固醇（HDL c）、LDL-胆固醇（LDL c）和甘油三酯（TG）水平。免疫比浊法测定载脂蛋白（apo）A-I、apoB和脂蛋白（a）[Lp（a）]值。主要结果指标。胎儿和母体血浆TChol、HDLc、LDLc、TG、apoA-I、apoB和Lp（a）水平。结果与正常孕妇相比，先兆子痫妇女的TChol、LDLc、HDLc、TG、apoA-I和apoB值显著较高。在先兆子痫妊娠的脐血中，我们观察到HDLc和apoA-I值显著降低，TG浓度和LDLc/HDLc比值显著升高。孕妇TG水平与PE严重程度的标志物蛋白尿呈正相关（r = 0.40，p < 0.01）。结论.我们的数据表明，先兆子痫妊娠与高脂血症有关，高脂血症似乎对胎儿血脂有负面影响，如较高的致动脉粥样硬化性LDLc/HDLc比值和较高的TG水平所反映的。这些孩子，出生的妇女与PE，可能值得在以后的生活中更密切的临床随访。
Objective. To evaluate the impact of maternal lipid changes upon the fetus in pre-eclampsia (PE) by evaluating lipid profile simultaneously in maternal and umbilical cord blood (UCB). Design. Case-control study performed on healthy and pre-eclamptic pregnant women and their neonates. Setting. The Department of Obstetrics and Gynecology, Hospital S. Joao and Faculty of Pharmacy, Porto, Portugal. Samples. Forty-two healthy pregnancies and 46 pregnancies complicated with PE. Methods. Total cholesterol (TChol), HDL-cholesterol (HDLc), LDL-cholesterol (LDLc) and triglycerides (TG) levels were determined using enzymatic methods. Apolipoprotein (apo) A-I, apoB and lipoprotein (a) [Lp(a)] values were measured by immunoturbidimetry. Main outcome measures. Fetal and maternal plasma levels of TChol, HDLc, LDLc, TG, apoA-I, apoB and Lp(a). Results. Pre-eclamptic women presented significantly higher values for TChol, LDLc, HDLc, TG, apoA-I and apoB compared to normal pregnant women. In the UCB from pre-eclamptic pregnancies, we observed significantly lower values for HDLc and apoA-I, and significantly higher TG concentrations and LDLc/HDLc ratio when compared to normal cases. A positive correlation was observed between maternal TG levels and proteinuria, a marker of PE severity (r = 0.40, p < 0.01). Conclusions. Our data suggest that pre-eclamptic pregnancy is associated with an enhanced hyperlipidemia, which seems to have a negative impact on fetal lipid profile, as reflected by a higher atherogenic LDLc/HDLc ratio and higher TG levels. These children, born of women with PE, may deserve a closer clinical follow-up later in life.