Type 2 diabetes and the risk of Parkinson's disease
Type 2 diabetes and the risk of Parkinson's disease
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DOI：
10.2337/dc06-2011
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发表时间：
2007-04-01
期刊：
影响因子：
16.2
通讯作者：
Tuomilehto, Jaakko
中科院分区：
文献类型：
--
作者：
Hu, Gang;Jousilahti, Pekka;Tuomilehto, Jaakko
目的：评估基线水平的2型糖尿病是否为帕金森病的危险因素。研究设计和方法：我们前瞻性地跟踪调查了基线时年龄在25-74岁之间、年龄在25-74岁之间的51552名无帕金森病史的芬兰男性和女性。糖尿病病史和其他研究参数在基线时使用标准化测量来确定。帕金森氏症病情的确定是基于全国社会保险机构的药物登记数据。结果：在平均18.0年的随访期内，324名男性和309名女性患上了帕金森氏症。在2型糖尿病患者中，年龄和研究年份调整后的帕金森病发病风险比与非2型糖尿病患者相比，男性为1.80(95%可信区间1.03-3.15)，女性为1.93(1.05-3.53)，男女合计为1.85(1.23-2.80)(也对性别进行了调整)。进一步调整BMI、收缩压、总胆固醇、教育程度、休闲体育活动、吸烟、饮酒以及喝咖啡和茶对结果的影响很小。分层亚组分析也证实了2型糖尿病与帕金森S病风险之间的多变量调整关联。结论--这些数据表明，2型糖尿病与帕金森病风险的增加有关。监测偏见可能是糖尿病发病率较高的原因。糖尿病和帕金森氏症之间的这种联系背后的机制尚不清楚。
OBJECTIVE - To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease.RESEARCH DESIGN AND METHODS - We prospectively followed 51,552 Finnish men and women 25-74 years of age without a history of Parkinson's disease at baseline. History of diabetes and other study parameters were determined at baseline using standardized measurements . Ascertainment of the Parkinson's disease status was based on the nationwide Social Insurance Institution's drug register data. Hazard ratios of incident Parkinson's disease associated with the history of type 2 diabetes were estimated.RESULTS - During a mean follow-up period of 18.0 years, 324 men and 309 women developed incident Parkinson's disease. Age- and study year-adjusted hazard ratios of incident Parkinson's disease among subjects with type 2 diabetes, compared with those without it, were 1.80 (95% CI 1.03-3.15) in men, 1.93 (1.05-3.53) in women, and 1.85 (1.23-2.80) in men and women combined (adjusted also for sex). Further adjustment for BMI, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, alcohol drinking, and coffee and tea consumption affected the results only slightly. The multivariate adjusted association between type 2 diabetes and the risk of Parkinson s disease was also confirmed in stratified subgroup analysis.CONCLUSIONS - These data suggest that type 2 diabetes is associated with an increased risk of Parkinson's disease. Surveillance bias might account for higher rates in diabetes. The mechanism behind this association between diabetes and Parkinson's disease is not known.