Possible Roles of Runx1 and Sox9 in Incipient Intramembranous Ossification
Possible Roles of Runx1 and Sox9 in Incipient Intramembranous Ossification
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DOI：
10.1359/jbmr.040801
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发表时间：
2004-10
影响因子：
6.2
通讯作者：
T. Yamashiro;Xiu-ping Wang;Zhe Li;Shinji Oya;T. Åberg;T. Fukunaga;H. Kamioka;N. Speck;T. Takano-Yamamoto;I. Thesleff
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文献类型：
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作者：
T. Yamashiro;Xiu-ping Wang;Zhe Li;Shinji Oya;T. Åberg;T. Fukunaga;H. Kamioka;N. Speck;T. Takano-Yamamoto;I. Thesleff
我们评估了RUNX1和Sox9在不同类型的骨形成中的详细表达模式，并确定RUNX1的表达是否受到Runx2缺乏的影响，Runx2的表达是否受到RUNX1缺乏的影响。我们的结果表明，RUNX1和SOX9在未来的成骨细胞室和软骨中都有强烈的表达。RUNX1和Sox9的表达模式表明，这两个基因都可能参与了颅面发育早期膜内骨的形成。
We evaluated the detailed expression patterns of Runx1 and Sox9 in various types of bone formation, and determined whether Runx1 expression was affected by Runx2 deficiency and Runx2 expression by Runx1 deficiency. Our results indicate that both Runx1 and Sox9 are intensely expressed in the future osteogenic cell compartment and in cartilage. The pattern of Runx1 and Sox9 expression suggests that both genes could potentially be involved in incipient intramembranous bone formation during craniofacial development.