Comparison of PCR-amplified JC virus control region sequences from multiple brain regions in PML
Comparison of PCR-amplified JC virus control region sequences from multiple brain regions in PML
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DOI：
10.1212/01.wnl.0000096147.47128.7d
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发表时间：
2003-12-09
期刊：
影响因子：
9.9
通讯作者：
Kato, S
中科院分区：
文献类型：
--
作者：
Yasuda, Y;Yabe, H;Kato, S
作者报告1例14岁男孩，患有Wiskott-Aldrich综合征，在异基因骨髓移植后并发进行性多灶性白质脑病。尝试了几种治疗方法，但没有任何反应。患者在出现神经症状2个月后死亡。我们在小脑、枕叶和脑干中检测到JC病毒的三个不同的重排区域。这些发现表明，脑损伤有三个独立的来源。
The authors report a 14-year-old boy with Wiskott - Aldrich syndrome complicated by progressive multifocal leukoencephalopathy after allogeneic bone marrow transplantation. Several therapeutic approaches were attempted, but there was no response. The patient died 2 months after the onset of neurologic symptoms. We detected three distinct, rearranged regions of JC virus in the cerebellum, occipital lobe, and brainstem. These findings suggest that the brain lesions had three independent origins.