The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity
The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity
复制标题
受体样激酶 NIK1 靶向 FLS2/BAK1 免疫复合物并反向调节抗病毒和抗菌免疫
DOI：
10.1038/s41467-019-12847-6
复制
发表时间：
2019-11-01
影响因子：
16.6
通讯作者：
Fontes, Elizabeth P. B.
中科院分区：
文献类型：
--
作者：
Li, Bo;Ferreira, Marco Aurelio;Fontes, Elizabeth P. B.
植物利用各种免疫受体来识别病原体并保护自己。不同病原体同时感染时，同一宿主内受体介导的信号转导通路之间可能发生串扰。然而，受体样激酶（RLKs）在阻止不同病原体中的相关功能仍然是难以捉摸的。在这里，我们报告说，NIK 1，积极调节植物抗病毒免疫，作为一个重要的负调节抗菌免疫。nik 1植物表现出矮小的形态，增强对细菌的抗病性和增加PAMP触发的免疫（PTI）的反应，这是恢复NIK 1重新引入。此外，NIK 1负调控FLS 2/BAK 1复合物的形成。NIK 1和FLS 2/BAK 1之间的相互作用在flg 22感知后增强，揭示了RLK的新型PTI调节机制。此外，flg 22感知在体内诱导NIK 1和RPL 10A磷酸化，激活抗病毒信号传导。NIK 1介导的抗病毒和抗菌免疫的逆调节可能允许细菌和病毒激活宿主相互对抗的免疫应答。
Plants deploy various immune receptors to recognize pathogens and defend themselves. Crosstalk may happen among receptor-mediated signal transduction pathways in the same host during simultaneous infection of different pathogens. However, the related function of the receptor-like kinases (RLKs) in thwarting different pathogens remains elusive. Here, we report that NIK1, which positively regulates plant antiviral immunity, acts as an important negative regulator of antibacterial immunity.nik1plants exhibit dwarfed morphology, enhanced disease resistance to bacteria and increased PAMP-triggered immunity (PTI) responses, which are restored by NIK1 reintroduction. Additionally, NIK1 negatively regulates the formation of the FLS2/BAK1 complex. The interaction between NIK1 and FLS2/BAK1 is enhanced upon flg22 perception, revealing a novel PTI regulatory mechanism by an RLK. Furthermore, flg22 perception induces NIK1 and RPL10A phosphorylation in vivo, activating antiviral signalling. The NIK1-mediated inverse modulation of antiviral and antibacterial immunity may allow bacteria and viruses to activate host immune responses against each other.