Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects.
Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects.
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白三烯 E4 对正常和哮喘受试者的支气管收缩作用。
DOI：
10.1164/arrd.1987.135.2.333
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Drazen,JM
中科院分区：
文献类型：
--
作者：
Davidson,AB;Lee,TH;Scanlon,PD;Solway,J;McFaddenJr,ER;IngramJr,RH;Corey,EJ;Austen,KF;Drazen,JM
本文比较了5例正常人和6例哮喘患者白三烯E4气雾剂(LTE4)和组胺的支气管收缩活性，以3种呼吸道反应指标确定LTE4的相对效力。测量部分和最大呼气动作的FEV1和肺活量30%时的流量。LTE4降低30%所需的几何平均浓度在正常组为0.3(1.46)mm，在哮喘组为0.058(1.63)mM，前者是组胺的39倍，后者是组胺的14倍。此外，我们观察到，当正常受试者和哮喘受试者在吸入组胺后支气管收缩程度导致LTE4下降30%时，哮喘组对伴随的FEV1变化的反应比正常组更大。吸入组胺后，两组FEV1的下降没有显著差异。这项研究表明，LTE4是一种在人类中有效的支气管收缩激动剂，并表明对该激动剂的气道反应性与用于评估呼吸道反应的支气管收缩指数有很大不同。
The bronchoconstrictor activity of an aerosol of leukotriene E4(LTE4) was compared with that of histamine in 5 normal and in 6 asthmatic subjects to define the relative potency of LTE4between the groups using 3 indices of airway response. The FEV1and the flow rate measured at 30% of vital capacity from partial and maximal expiratory maneuvers ( and ) were measured. The geometric mean (GSEM) concentration of LTE4required to reduce the by 30% was 0.30(1.46) mM in the normal subjects, and 0.058 (1.63) in the asthmatic subjects; LTE4was 39-fold more potent than histamine in the former and 14-fold in the latter group. Further, we observed that when normal and asthmatic subjects were compared at a degree of bronchoconstriction resulting in a 30% decrement in the after inhaling LTE4, there was a greater response in the asthmatic group than in the normal group of the accompanying change in the FEV1.The decrements in the FEV1were not significantly different between the 2 groups after inhaling histamine. This study demonstrates that LTE4is a potent bronchoconstrictor agonist in humans and suggests that airway responsiveness to this agonist differs substantially with the index of bronchoconstriction used for assessment Of airway response.