Renal transplantation after myeloablative and non‐myeloablative hematopoietic cell transplantation from the same donor
Renal transplantation after myeloablative and non‐myeloablative hematopoietic cell transplantation from the same donor
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来自同一供体的清髓性和非清髓性造血细胞移植后的肾移植
DOI：
10.1111/j.1442-2042.2007.01877.x
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发表时间：
2007
影响因子：
2.6
通讯作者：
K. Tanabe
中科院分区：
文献类型：
--
作者：
Toshiaki Tanaka;H. Ishida;H. Shirakawa;H. Amano;H. Nishida;K. Tanabe
摘要： 造血细胞移植是延长多种血液疾病患者生存期的关键治疗方法。肾损伤被公认为是造血细胞移植的一个重要并发症，可进展为终末期肾病。在此，我们报告两名患者接受肾移植的经历，该患者的肾移植来自同一供体，该供体为先前的造血细胞移植提供了细胞。一名患者接受了非清髓性预处理方案的外周血干细胞移植，而另一名患者则接受了清髓性方案的骨髓移植。两者都不需要长期免疫抑制治疗来维持肾移植功能。不仅采用清髓预处理方案的骨髓移植，而且采用非清髓方案的外周血干细胞移植都可以赋予免疫耐受。
Abstract: Hematopoietic cell transplantation is a key treatment to prolong patient survival for many hematological disorders. Renal impairment is well recognized as a significant complication of hematopoietic cell transplantation, which can progress to end‐stage renal disease. Herein, we report our experience of two patients who underwent renal transplantation from the same donor who provided cells for the preceding hematopoietic cell transplantation. One patient had undergone peripheral blood stem cell transplantation with a non‐myeloablative conditioning regimen, whereas the other had received bone marrow transplantation with a myeloablative regimen. Chronic immunosuppressive therapy was not needed in either one to maintain the kidney graft function. Not only bone marrow transplantation with a myeloablative conditioning regimen, but also peripheral blood stem cell transplantation with a non‐myeloablative regimen can confer immunological tolerance.