Vitamin D immunoregulation through dendritic cells.
Vitamin D immunoregulation through dendritic cells.
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DOI：
10.1111/imm.12610
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发表时间：
2016-07
期刊：
影响因子：
6.4
通讯作者：
Butcher EC
中科院分区：
文献类型：
--
作者：
Bscheider M;Butcher EC
维生素D（VD3）与免疫过程有关，其补充可能在治疗或预防潜在自身免疫或促炎状态的疾病中发挥作用。作为免疫应答的启动者，树突状细胞（DC）是VD3抑制自身免疫和炎症的潜在靶点，但DC在VD3介导的体内免疫调节中的作用尚不清楚。除了作为VD3的靶点外，DC还可以提供生物活性VD3的局部来源，用于调节T细胞应答。在这里，我们回顾了现有的研究，描述了VD3对DC的耐受性潜力，并讨论他们在目前的背景下了解DC的发展和功能。我们推测的机制，可能占有效的，但知之甚少的VD3和DC作为这种激素的目标和来源的作用致耐受性的活动。
Vitamin D (VD3) has been linked to immunological processes, and its supplementation may have a role in treatment or prevention of diseases with underlying autoimmune or pro‐inflammatory states. As initiators of the immune responses, dendritic cells (DC) are a potential target of VD3 to dampen autoimmunity and inflammation, but the role of DC in VD3‐mediated immunomodulation in vivo is not understood. In addition to being targets of VD3, DC can provide a local source of bioactive VD3 for regulation of T‐cell responses. Here we review existing studies that describe the tolerogenic potential of VD3 on DC, and discuss them in the context of current understanding of DC development and function. We speculate on mechanisms that might account for the potent but poorly understood tolerogenic activities of VD3 and the role of DC as both targets and sources of this hormone.