Long-term Mild Exercise Training Enhances Hippocampus-dependent Memory in Rats
Long-term Mild Exercise Training Enhances Hippocampus-dependent Memory in Rats
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DOI：
10.1055/s-0034-1390465
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发表时间：
2015-04-01
影响因子：
2.5
通讯作者：
Soya, H.
中科院分区：
文献类型：
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作者：
Inoue, K.;Hanaoka, Y.;Soya, H.
尽管运动训练可以改善海马相关认知，但最佳运动强度仍存在争议。基于大鼠的乳酸盐阈值（LT，在跑步机上大约20 m/min），我们已经表明，2周的无压力轻度运动（ME，LT）训练（包括运动应激）促进成年海马神经发生（Okamoto等人，PNAS，2012），一种潜在的记忆改善基质。这些结果使我们假设，长期ME，而不是IE，训练导致改善海马功能的评估与莫里斯水迷宫（MWM）任务。为了验证这一假设，我们调查了生理应激水平和MWM任务性能的变化，大鼠分配到6周的久坐控制（CONT），ME训练或IE训练条件。结果表明，与其他条件相比，只有IE引起全身适应综合征（GAS），包括肾上腺肥大，胸腺萎缩和高皮质酮血症。在MWM中，与CONT相比，ME导致增强的记忆，但不是学习，而IE在两种能力上都没有变化，可能是由于GAS。这些发现支持了这样的假设，即6周的持续ME训练会增强与记忆有关的记忆，这可能对健康成年人和体能低下的受试者都有影响。
Although exercise training improves hippocampus-related cognition, the optimum exercise intensity is still disputed. Based on the lactate threshold (LT, approximately 20 m/min on treadmill) of rats, we have shown that 2 weeks of training with stress-free mild exercise (ME, LT), comprising exercise stress, promotes adult hippocampal neurogenesis (Okamoto et al., PNAS, 2012), a potential substrate for memory improvement. These results led us to postulate that long-term ME, but not IE, training leads to improved hippocampal function as assessed with a Morris water maze (MWM) task. To test this hypothesis, we investigated the changes in physiological stress levels and MWM task performance in rats assigned to 6 weeks of sedentary control (CONT), ME-training or IE-training conditions. Results showed that, compared to the other conditions, only IE causes general adaptive syndrome (GAS), including adrenal hypertrophy, thymic atrophy and hypercorticosteronemia. In the MWM, ME led to enhanced memory, but not learning, compared with CONT, while IE produced no change in either capacity, probably due to GAS. These findings support the hypothesis that 6 weeks of continuous ME training leads to enhanced hippocampus-related memory, which may have implications for both healthy adults and subjects with low physical capacity.