Pharmacokinetics of thiopental in the asphyxiated neonate.
Pharmacokinetics of thiopental in the asphyxiated neonate.
复制标题
硫喷妥钠在窒息新生儿中的药代动力学。
DOI：
10.1159/000457691
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
D. Weidler
中科院分区：
文献类型：
--
作者：
D. Garg;R. Goldberg;R. Woo‐Ming;D. Weidler
作为一项随机对照试验的一部分，在 10 名窒息新生儿（平均值 +/- SE；出生体重，3,244 +/- 212 g；胎龄，40 +/- 1 周）中研究了硫喷妥钠的药代动力学特性，该试验测试了巴比妥类疗法减少围产期窒息继发的中枢神经系统损伤的能力。治疗在平均年龄 2.3 小时开始，最初在 30 分钟内给予 15 mg/kg 的负荷剂量，然后持续输注。平均稳态硫喷妥钠浓度为 13.4 +/- 3.7 微克/ml（平均值 +/- SD），达到稳态的平均时间为 7 +/- 5 小时。硫喷妥钠的平均消除半衰期、血浆清除率和分布容积分别为 39 小时（范围 26-70）、66 ml/（h x kg）（范围 31-172）和 3.6 升/kg（范围 1.1-6.7）。 10 名患者中有 8 名需要动脉血压支持。虽然按照报告的输注速度给窒息新生儿注射硫喷妥钠似乎是可行的，但由于频繁发生低血压和需要药物血压支持，风险效益比会增加。
The pharmacokinetic properties of thiopental were studied in 10 asphyxiated neonates (mean +/- SE; birth weight, 3,244 +/- 212 g; gestational age, 40 +/- 1 weeks) as part of a randomized, controlled trial which tested the ability of barbiturate therapy to decrease central nervous system damage secondary to perinatal asphyxia. Therapy was begun at a mean age of 2.3 h in all and was initially given as a loading dose of 15 mg/kg over 30 min followed by a constant infusion. The mean steady-state thiopental concentration was 13.4 +/- 3.7 micrograms/ml (mean +/- SD) and the average time to reach steady state was 7 +/- 5 h. Mean elimination half-life, plasma clearance and volume of distribution for thiopental were 39 h (range 26-70), 66 ml/(h x kg) (range 31-172), and 3.6 liters/kg (range 1.1-6.7), respectively. Arterial blood pressure support was required in 8 of 10 patients. While it appears feasible to give thiopental to the asphyxiated neonate at the reported infusion rates, the risk-benefit ratio is increased by the frequent associated hypotension and need for pharmacologic blood pressure support.