Genetic Determinants in Hepatic Fibrosis: From Experimental Models to Fibrogenic Gene Signatures in Humans
Genetic Determinants in Hepatic Fibrosis: From Experimental Models to Fibrogenic Gene Signatures in Humans
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DOI：
10.1016/j.cld.2008.07.012
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发表时间：
2008-11-01
影响因子：
5.1
通讯作者：
Lammert, Frank
中科院分区：
文献类型：
--
作者：
Weber, Susanne;Gressner, Olav A.;Lammert, Frank
肝纤维化或肝瘢痕形成是慢性肝损伤的非特异性反应。肝纤维化通常是由外源性因素引起的，如病毒性肝炎或酗酒，但最近的研究也表明遗传易感性。尽管一些慢性肝病患者仅表现出肝脏的微小形态和功能改变，并且以疾病进展缓慢伴轻度临床症状为特征，但其他患者迅速发展为明显的肝纤维化，分别最终导致肝硬化、肝衰竭或肝细胞癌。在多变量分析中，当控制年龄（感染时）、性别和外源性因素时，这些众所周知的肝纤维化进展差异仍然存在，表明遗传因素可能在肝纤维化的调节中起重要作用，并导致纤维化进展的变异性。本文就肝纤维化的遗传因素作一综述。
Hepatic fibrosis, or scarring of the liver, is a nonspecific reaction to chronic liver injury. Hepatic fibrosis is commonly caused by exogenous factors such as viral hepatitis or alcohol abuse, but recent studies also indicate a genetic predisposition. Although some patients who have chronic liver diseases show only minor morphologic and functional alterations of the liver and are characterized by slow progression of disease with mild clinical symptoms, others develop pronounced hepatic fibrosis rapidly, culminating in cirrhosis, liver failure, or hepatocellular carcinoma, respectively. These well known differences in progression of hepatic fibrosis persist when controlling for age (at infection), gender, and exogenous factors in multivariate analysis, indicating that genetic factors might play important roles in the modulation of hepatic fibrosis and contribute to the variability in fibrosis progression. This review summarizes genetic determinants in hepatic fibrosis.