Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidus
Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidus
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DOI：
10.3171/jns/2008/109/7/0130
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发表时间：
2008-07-01
影响因子：
4.1
通讯作者：
Coubes, Philippe
中科院分区：
文献类型：
--
作者：
Biolsi, Brigitte;Cif, Laura;Coubes, Philippe
脑深部刺激现在被认为是一种安全有效的治疗运动障碍的方法，包括某些类型的肌张力障碍和运动障碍。然而，人们对它对其他运动障碍的影响知之甚少，特别是对“舞蹈”运动的影响。亨廷顿病是一种致命的常染色体显性神经退行性疾病，以运动障碍、进行性认知障碍和精神症状为特征。对一名60岁的亨廷顿病患者进行双侧慢性内苍白球刺激，以控制舞蹈性运动。慢性深部脑刺激可显著改善舞蹈动作。术后改善持续4年，日常生活质量显著改善。
Deep brain stimulation is now accepted as a safe and efficient treatment for movement disorders including selected types of dystonia and dyskinesia. Very little, however, is known about its effect on other movement disorders, particularly for "choreic" movements. Huntington disease is a fatal autosomal-dominant neurodegenerative disorder characterized by movement disorders, progressive cognitive impairment, and psychiatric symptoms. Bilateral chronic stimulation of the internal globus pallidus was performed to control choreic movements in a 60-year-old man with a 10-year history of Huntington disease. Chronic deep brain stimulation resulted in remarkable improvement of choreic movements. Postoperative improvement was sustained after 4 years of follow-up with a marked improvement in daily quality of life.