The molecular biophysics of extracellular vimentin and its role in pathogen-host interactions.
The molecular biophysics of extracellular vimentin and its role in pathogen-host interactions.
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DOI：
10.1016/j.ceb.2023.102233
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发表时间：
2023-09
影响因子：
7.5
通讯作者：
Sepideh Parvanian;Leila S. Coelho-Rato;John E. Eriksson;Alison E. Patteson
中科院分区：
文献类型：
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作者：
Sepideh Parvanian;Leila S. Coelho-Rato;John E. Eriksson;Alison E. Patteson
波形蛋白是一种通常位于间充质细胞细胞质中的中间丝蛋白，也可以作为细胞外蛋白分泌。细胞外波形蛋白的组织强烈决定其在生理和病理条件下的功能，使其成为未来治疗干预的有希望的靶点。已发现波形蛋白的细胞外形式在宿主细胞和病原体之间的相互作用中起作用。在这篇综述中，我们首先讨论了细胞外波形蛋白的分子生物物理学，包括其结构，分泌和粘附特性。然后，我们提供了一个一般性的概述细胞外波形蛋白介导的病原体-宿主相互作用的作用，重点是它与病毒和细菌的相互作用。我们还讨论了这些发现的影响，为打击传染病的新的治疗策略的发展。
Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.