Ifosfamide neuropsychiatric toxicity in patients with cancer
Ifosfamide neuropsychiatric toxicity in patients with cancer
复制标题
DOI：
10.1002/pon.1161
复制
发表时间：
2007-10-01
期刊：
影响因子：
3.6
通讯作者：
Breitbart, William S.
中科院分区：
文献类型：
--
作者：
Alici-Evcimen, Yesne;Breitbart, William S.
异环磷酰胺是一种化疗药物，常用于治疗几种实体瘤和恶性血液病。常见的异环磷酰胺毒性为骨髓抑制、脱发、恶心和呕吐。不太常见但引人注目的是罕见但显著的神经精神毒性，伴有离散的神经系统症状和谵妄。我们在此报告一例异环磷酰胺神经精神毒性的病例，表现为孤立的精神障碍伴妄想，并经亚甲蓝成功治疗。目前的文献治疗和预防这种临床上具有挑战性的化疗引起的并发症。版权所有（C）2007约翰威利父子有限公司
Ifosfamide is a chemotherapy agent commonly used in the treatment of several solid tumors and hematologic malignancies. Common ifosfamide toxicities are bone marrow suppression, alopecia, nausea and vomiting. Less common, but striking, are the rare but dramatic neuropsychiatric toxicities with discrete neurological symptoms and delirium. We report here a case of ifosfamide neuropsychiatric toxicity which presented with an isolated psychotic disorder with delusions, and was successfully treated with methylene blue. Current literature on treatment and prophylaxis of this clinically challenging chemotherapy-induced complication is presented. Copyright (C) 2007 John Wiley & Sons, Ltd.