A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer
A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer
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DOI：
10.1016/j.lungcan.2010.04.016
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发表时间：
2011-02-01
期刊：
影响因子：
5.3
通讯作者：
Zienolddiny, Shanbeh
中科院分区：
文献类型：
--
作者：
Hart, Kent;Landvik, Nina E.;Zienolddiny, Shanbeh
暴露于烟草烟雾以及环境和职业因素是肺癌的主要原因。非小细胞肺癌(NSCLC)是肺癌的主要组织学类型。影响炎症、细胞应激和细胞凋亡途径的基因很重要，改变这些反应的基因多态性可能会影响肺部炎症的程度。在目前的研究中，我们调查了炎症相关基因的潜在功能多态组合是否可能调节非小细胞肺癌的风险。对来自挪威人群的882名受试者中9个基因的11个功能多态与非小细胞肺癌风险进行了分析。结果显示，携带caspase-8、基质金属蛋白1、硒蛋白S1和白介素10基因3种功能多态的个体患NSCLC的风险增加2倍(OR 2.06(95%CI，1.19-3.47)，而携带4种风险基因的个体的风险增加4.62倍(OR 4.62，95%CI，1.69-12.63)。这些结果强调了研究多个SNPs在肺癌发生中的联合作用的必要性。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
Exposure to tobacco smoke as well as environmental and occupational factors is the major cause of lung cancer. Non-small cell lung cancer (NSCLC) is the major histological type. Genes in pathways affecting inflammation, cellular stress and apoptosis are important, and the extent of inflammation in the lung could be affected by polymorphisms modifying these responses. In the present study we have investigated whether a combination of potential functional polymorphisms in genes related to inflammation may modulate risk of NSCLC. Eleven functional polymorphisms in nine genes were analyzed for association with risk of NSCLC in 882 subjects from the Norwegian population. The results showed that individuals carrying combination of three functional polymorphisms in the caspase-8, matrix metalloproteinase1, seleno-protein S1, and interleukin-10 genes had two-fold increased risk of NSCLC (OR 2.06 (95% Cl, 1.19-3.47) whereas individuals with four risk genotypes had 4.62-fold increased risk (OR 4.62, 95% Cl, 1.69-12.63). These results highlight the need to investigate the combinatory effects of multiple SNPs in the carcinogenesis of the lung. (C) 2010 Elsevier Ireland Ltd. All rights reserved.