Mother-child interaction and cognitive development in children prenatally exposed to methadone or buprenorphine
Mother-child interaction and cognitive development in children prenatally exposed to methadone or buprenorphine
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DOI：
10.1016/j.earlhumdev.2016.08.013
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发表时间：
2016-10-01
影响因子：
2.5
通讯作者：
Melinder, Annika
中科院分区：
文献类型：
--
作者：
Konijnenberg, Carolien;Sarfi, Monica;Melinder, Annika
目的：为了评估母婴互动对儿童认知发育的影响，在一组产前暴露于美沙酮或丁丙诺啡的儿童。研究设计：这项研究是一个前瞻性纵向项目的一部分，调查阿片类药物维持治疗（OMT）的妇女所生的孩子的发展。样本包括2005年和2007年之间出生的67名儿童，其中35产前暴露于美沙酮或丁丙诺啡和32个非暴露的比较children.Results：两组得分在正常范围内的发展。然而，与对照组相比，OMT组在认知发展和母子互动方面的得分明显较低。认知发展被发现受到两组状态的影响，F（1，54）= 5.65，p = 0.02，n（2）= 0.10，母子互动F（1，54）= 526，p = 0.03。n（2）= 0.09。行为抑制（雕像），感觉运动功能（模仿手的位置），和短期记忆（句子）的影响组的地位，而叙事记忆和词汇被发现更多的影响母子interaction.Conclusions：不同的危险因素可能会影响不同的认知功能的妇女在OMT的儿童。具体而言，语言相关的认知技能可能与母婴互动更相关，而需要精确控制感觉运动反应的高级认知功能的表现可能对其他因素更敏感，如产前OMT暴露，遗传学和/或产前暴露于其他物质。(c)2016爱思唯尔爱尔兰有限公司版权所有。
Objective: To assess the influence of mother-child interaction on children's cognitive development in a group of children prenatally exposed to methadone or buprenorphine.Study design: The study is part of a prospective longitudinal project investigating the development of children born to women in opioid maintenance therapy (OMT). The sample includes 67 children born between 2005 and 2007, 35 of which prenatally exposed to either methadone or buprenorphine and 32 non-exposed comparison children.Results: Both groups scored within the normal range of development. However, the OMT group scored significantly lower on measures of cognitive development and mother-child interaction compared to the comparison group. Cognitive development was found to be affected by both group status, F(1,54) = 5.65, p = 0.02, n(2) = 0.10 and mother-child interaction F(1,54) = 526,p = 0.03. n(2) = 0.09. Behavioral inhibition (statue), sensorimotor function (imitating hand positions), and short-term memory (sentences) was influenced by group status while narrative memory and vocabulary were found to be more influenced by mother-child interaction.Conclusions: Different risk factors may influence different cognitive functions in children of women in OMT. Specifically, language-related cognitive skills may be more related to mother-child interaction while performance in higher cognitive functions requiring precise control over sensorimotor responses may be more sensitive to other factors such as prenatal OMT exposure, genetics, and/or prenatal exposure to other substances. (c) 2016 Elsevier Ireland Ltd. All rights reserved.