Biological applications of copper-containing materials.
Biological applications of copper-containing materials.
复制标题
含铜材料的生物学应用
DOI：
10.1016/j.bioactmat.2020.09.017
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发表时间：
2021-04
影响因子：
18.9
通讯作者：
Qi X
中科院分区：
文献类型：
--
作者：
Wang P;Yuan Y;Xu K;Zhong H;Yang Y;Jin S;Yang K;Qi X
铜是人体不可缺少的痕量金属元素，主要在胃和小肠吸收，并排入胆汁。铜是体内多种酶和蛋白质的重要成分和催化剂，可通过多种机制影响人体健康。基于铜的生物学功能和益处，越来越多的生物材料研究人员致力于开发新型的含铜生物材料，这些材料在保护心血管系统、促进骨折愈合和发挥抗菌作用方面具有独特的性能。铜还可用于促进伤口愈合、杀死癌细胞、正电子发射断层扫描(PET)成像、放射免疫示踪和癌症放射治疗。本文介绍了铜在人体内的生物学功能，并综述了含铜材料在生物应用和开发方面的最新进展。此外，本文还对这些新型生物材料在未来临床应用中面临的挑战进行了展望。本文综述了铜在人体内的生物学功能。本文综述了近年来含铜生物材料在生物应用和开发方面的研究进展。本文着重阐述了含铜生物材料的有益作用及其相关机理。本文还对这些新型生物材料在未来临床应用中面临的挑战进行了展望。
Copper is an indispensable trace metal element in the human body, which is mainly absorbed in the stomach and small intestine and excreted into the bile. Copper is an important component and catalytic agent of many enzymes and proteins in the body, so it can influence human health through multiple mechanisms. Based on the biological functions and benefits of copper, an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials, which exhibit unique properties in protecting the cardiovascular system, promoting bone fracture healing, and exerting antibacterial effects. Copper can also be used in promoting incisional wounds healing, killing cancer cells, Positron Emission Tomography (PET) imaging, radioimmunological tracing and radiotherapy of cancer. In the present review, the biological functions of copper in the human body are presented, along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials. Furthermore, this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications. This paper overviews biological functions of copper in the human body. This paper summerizes the recent research progress of the biological applications and development of copper-containing biomaterials. This paper is emphasized on the beneficial effects and related mechanisms of Cu-containing biomaterials. This review also provides the prospective on the challenges of these novel biomaterials for future clinical applications.
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影响因子：
39.3
作者：
Byrne RA;Joner M;Kastrati A
通讯作者：
Kastrati A
影响因子：
17.1
作者：
Atkinson RL;Zhang M;Diagaradjane P;Peddibhotla S;Contreras A;Hilsenbeck SG;Woodward WA;Krishnan S;Chang JC;Rosen JM
通讯作者：
Rosen JM
影响因子：
14.9
作者：
Bao L;Chen Y;Lai HT;Wu SY;Wang JE;Hatanpaa KJ;Raisanen JM;Fontenot M;Lega B;Chiang CM;Semenza GL;Wang Y;Luo W
通讯作者：
Luo W
影响因子：
39.3
作者：
Boren, Jan;Chapman, M. John;Ginsberg, Henry N.
通讯作者：
Ginsberg, Henry N.
影响因子：
8.8
作者：
Cai, Dian-Geng;Bao, Mian-Mian;Zhang, Er-Lin
通讯作者：
Zhang, Er-Lin