ENDOCYTOSIS OF RED BLOOD-CELLS OR HEMOGLOBIN BY ACTIVATED MACROPHAGES INHIBITS THEIR TUMORICIDAL EFFECT
ENDOCYTOSIS OF RED BLOOD-CELLS OR HEMOGLOBIN BY ACTIVATED MACROPHAGES INHIBITS THEIR TUMORICIDAL EFFECT
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DOI：
10.1038/269245a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
HIBBS, JB
中科院分区：
文献类型：
--
作者：
WEINBERG, JB;HIBBS, JB
慢性卡介苗（BCG）或弓形虫感染的小鼠对肿瘤生长的抵抗力增加，这些小鼠的腹腔巨噬细胞可以通过非吞噬方式选择性地体外杀死肿瘤细胞1，2。虽然杀伤的实际分子机制尚不清楚，但可能涉及杀肿瘤巨噬细胞（TM）空泡系统。相位对比3和电子显微镜研究4表明TM溶酶体易位到肿瘤细胞中，随后肿瘤细胞死亡。台盼蓝（一种溶酶体酶抑制剂）或氢化可的松（一种膜稳定剂和膜融合抑制剂）将抑制TM对体外肿瘤细胞的杀伤作用（参考文献3）。我们在这里报告，内吞的红细胞（RBC），血红蛋白或血红蛋白降解产物的TM抑制其tummoricidal效果。
MICE with chronic Bacillus Calmette-Guérin (BCG) orToxoplasma gondiiinfection have increased resistance to tumour growth, and peritoneal macrophages from these mice can selectively kill neoplastic cellsin vitroby non-phagocytic means1,2. Although the actual molecular mechanism of killing is unknown, the tumoricidal macrophage (TM) vacuolar system is probably involved. Phase contrast3and electron microscopy studies4have suggested the translocation of TM lysosomes into tumour cells with subsequent tumour cell death. Trypan blue, an inhibitor of lysosomal enzymes, or hydrocortisone, a membrane stabiliser and inhibitor of membrane fusion, will suppress thein vitrotumour cell killing by TM (ref. 3). We report here that endocytosis of red blood cells (RBC), haemoglobin or haemoglobin degradation products by TM inhibits their turmoricidal effect.