Fungal regulatory evolution: cis and trans in the balance.
Fungal regulatory evolution: cis and trans in the balance.
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真菌调控进化：顺式和反式的平衡。
DOI：
10.1016/j.febslet.2009.11.032
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发表时间：
2009
期刊：
影响因子：
3.5
通讯作者：
Regev,Aviv
中科院分区：
文献类型：
--
作者：
Thompson,DawnAnne;Regev,Aviv
监管分歧可能是进化的主要驱动力。比较基因组学正越来越多地用于推断基因调控的进化。由于广泛的系统发育范围，许多测序的基因组和基因组分析的易处理性，子囊菌门真菌是唯一适合于真核生物中的调控进化研究。在这里，我们回顾了最近的进展，在确定的贡献，顺式和反式因子的表达分歧。虽然目前的策略已经导致了令人惊讶的签名和机制的发现，我们仍然对监管进化的适应性作用知之甚少。包括实验进化，比较功能基因组学和杂交和工程菌株的实证研究显示出早期的承诺，破译的监管分歧适应的贡献。
Regulatory divergence is likely a major driving force in evolution. Comparative genomics is being increasingly used to infer the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for regulatory evolution studies, due to broad phylogenetic scope, many sequenced genomes, and tractability of genomic analysis. Here we review recent advances in the identification of the contribution of cis- and trans-factors to expression divergence. Whereas current strategies have led to the discovery of surprising signatures and mechanisms, we still understand very little about the adaptive role of regulatory evolution. Empirical studies including experimental evolution, comparative functional genomics and hybrid and engineered strains are showing early promise toward deciphering the contribution of regulatory divergence to adaptation.