Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain
Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain
复制标题
DOI：
10.1016/j.ejphar.2006.04.021
复制
发表时间：
2006-07-01
影响因子：
5
通讯作者：
Hashimoto, Atsushi
中科院分区：
文献类型：
--
作者：
Takeyama, Kazuhide;Yoshikawa, Masanobu;Hashimoto, Atsushi
我们评估了非竞争性 N-甲基-D-天冬氨酸受体拮抗剂酮汀的急性给药对大鼠几个脑区丝氨酸消旋酶和 D-氨基酸氧化酶 mRNA 表达的影响。服用氯胺酮后，所有脑区的丝氨酸消旋酶和 D-氨基酸氧化酶 mRNA 水平出现剂量依赖性短暂升高。这些发现表明 D-丝氨酸相关酶的基因表达与 N-甲基-D-天冬氨酸受体的阻断之间存在关系。 (c) 2006 Elsevier B.V 保留所有权利。
We have evaluated the effects of the acute administration of noncompetitive N-methyl-D-aspartate receptor antagonist, ketantine, on the expression of serine racemase and D-amino acid oxidase mRNAsin several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the D-serine-related enzymes and the blockade of the N-methyl-D-aspartate receptors. (c) 2006 Elsevier B.V All rights reserved.