The pharmacology of cerebral vasospasm.
The pharmacology of cerebral vasospasm.
复制标题
脑血管痉挛的药理学。
作者：
D. Cook
蛛网膜下腔出血后3天左右，脑血管常出现持续性收缩(脑血管痉挛)，发病率和死亡率增加。对文献的研究表明，血红蛋白、各种前列腺素的相互作用以及其他一些因素可能是导致这种情况的原因，显然与内皮损伤或其他结构变化有关。最有希望的治疗方法是使用钙拮抗剂。
About 3 days after subarachnoid hemorrhage the cerebral blood vessels often undergo a sustained constriction (cerebral vasospasm) which is associated with increased morbidity and mortality. Examination of the literature suggests that interactions of hemoglobin, various prostaglandins, and perhaps some other agents are responsible for this condition, which is apparently associated with endothelial damage or other structural changes. The most promising therapy involves treatment with calcium antagonists.