Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
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发表时间：
1994-06
期刊：
影响因子：
11.2
通讯作者：
Toshinari Minamoto;K. Sawaguchi;Masayoshi Mai;N. Yamashita;Takashi Sugimura;Hiroyasu Esumi
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文献类型：
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作者：
Toshinari Minamoto;K. Sawaguchi;Masayoshi Mai;N. Yamashita;Takashi Sugimura;Hiroyasu Esumi
越来越多的临床病理学证据表明，浅表型（扁平）结直肠肿瘤是一种独特的肿瘤实体。为了阐明该肿瘤的遗传特征，我们研究了43个该类型肿瘤的K-ras基因突变和形态学特征。在 31 个腺瘤中仅检测到 5 个（16%），在 12 个腺癌中仅检测到 2 个（17%）存在 K-ras 密码子 12 突变。这种突变的存在或不存在与肿瘤大小或阶段或组织病理学结果无关。这些肿瘤的密码子 13 或外显子 2（包括密码子 61）均不存在突变。K-ras 突变发生率较低（16%），表明浅表型结直肠肿瘤在病因学上与普通结直肠息肉样肿瘤不同，结直肠肿瘤发生可能存在其他途径。
Clinicopathological evidence is accumulating that a superficial-type (flat) colorectal tumor is a distinct neoplastic entity. To clarify the genetic characteristics of this tumor, we investigated the K-ras gene mutations and morphological features of 43 tumors of this type. A mutation of the K-ras codon 12 was detected in only 5 (16%) of 31 adenomas and 2 (17%) of 12 adenocarcinomas. The presence or absence of this mutation was not correlated with the tumor size or stage or with histopathological findings. None of these tumors had a mutation in codon 13 or exon 2, including codon 61. This low incidence of K-ras mutations (16%) suggests that superficial-type colorectal tumors are etiologically distinct from ordinary colorectal polypoid tumors and that there may be an alternative pathway of colorectal tumorigenesis.