Principles of PET/MR Imaging
Principles of PET/MR Imaging
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DOI：
10.2967/jnumed.113.129098
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发表时间：
2014-06-01
影响因子：
9.3
通讯作者：
Pichler, Bernd J.
中科院分区：
文献类型：
--
作者：
Disselhorst, Jonathan A.;Bezrukov, Ilja;Pichler, Bernd J.
混合PET/MR系统已经从原型阶段迅速发展到越来越多地在临床中使用的系统。本文综述了混合PET/MR系统的发展，并总结了PET/MR仪器、校正技术和数据分析的最新进展。强磁场要求在获取PET图像的方式上有相当大的变化，并导致了新的PET探测器的发展，例如硅光电倍增管。在十多年的活跃的PET/MR发展过程中，已经描述了几种系统设计。解释了PET/MR组合系统的技术背景，并讨论了相关的挑战。PET衰减校正的必要性需要新的基于MR数据的方法。因此，本文概述了这一领域的最新发展。此外，还讨论了基于MR的PET运动校正技术，因为集成的PET/MR系统提供了一个无需额外仪器即可测量高时间分辨率运动的平台。PET/MR系统中的MR组件可以提供有关疾病过程或大脑功能的功能信息，并提供解剖图像。在此背景下，我们指出了多模式分子成像这一新领域的数据分析的新机遇。
Hybrid PET/MR systems have rapidly progressed from the prototype stage to systems that are increasingly being used in the clinics. This review provides an overview of developments in hybrid PET/MR systems and summarizes the current state of the art in PET/MR instrumentation, correction techniques, and data analysis. The strong magnetic field requires considerable changes in the manner by which PET images are acquired and has led, among others, to the development of new PET detectors, such as silicon photomultipliers. During more than a decade of active PET/MR development, several system designs have been described. The technical background of combined PET/MR systems is explained and related challenges are discussed. The necessity for PET attenuation correction required new methods based on MR data. Therefore, an overview of recent developments in this field is provided. Furthermore, MR-based motion correction techniques for PET are discussed, as integrated PET/MR systems provide a platform for measuring motion with high temporal resolution without additional instrumentation. The MR component in PET/MR systems can provide functional information about disease processes or brain function alongside anatomic images. Against this background, we point out new opportunities for data analysis in this new field of multimodal molecular imaging.